Korean J Pediatr.  2009 Feb;52(2):187-193. 10.3345/kjp.2009.52.2.187.

Serum level of the adiponectin and adiponectin I164T polymorphism in hypertensive adolescents

• Lee JA
• Gil JH
• Hong YM

• KMID: 2281674
• DOI: http://doi.org/10.3345/kjp.2009.52.2.187

Abstract

PURPOSE: Adiponectin is a molecule that plays an important role in the metabolic syndrome. In addition, its concentration is known to be decreased in obesity, type 2 diabetes, and coronary artery disease. Although a relationship between hypertension and serum adiponectin concentrations has been reported by several authors, such findings continue to be debated. We investigated whether hypoadiponectinemia is related to hypertension in adolescents and studied the associated genetic polymorphism.
METHODS
Forty hypertensive adolescents (Age 16-17 years old) and twenty normotensive matched subjects were included. Serum adipo-nectin, insulin, renin, aldosterone and angiotensin converting enzyme (ACE) levels were compared. Their carotid intima-media thickness (cIMT) and pulse wave velocity (PWV) were measured. Polymorphisms of the adiponectin I164T gene were investigated using polymerase chain reaction (PCR).
RESULTS
The hypertensive adolescents had significantly greater cIMT and PWV. In addition, the serum aldosterone, renin and insulin levels were significantly higher in the hypertensive group. The plasma concentrations of adiponectin did not differ significantly between the two groups. TC genotype was not found in our study subjects; they all had the TT genotype of the adiponectine gene.
CONCLUSION
The results of our study showed that adiponectin levels were not significantly different in adolescents with hypertension. There was no distinctive genetic polymorphism observed in this group of patients. Further large scale studies are needed to clarify the association between genetic variations and adiponectin in hypertensive adolescents.

Keyword

Adiponectin; Hypertension; Adolescent

MeSH Terms

Adiponectin
Adolescent
Aldosterone
Carotid Intima-Media Thickness
Coronary Artery Disease
Genetic Variation
Genotype
Humans
Hypertension
Insulin
Metabolism, Inborn Errors
Obesity
Peptidyl-Dipeptidase A
Plasma
Polymerase Chain Reaction
Polymorphism, Genetic
Pulse Wave Analysis
Renin
Adiponectin
Aldosterone
Insulin
Metabolism, Inborn Errors
Peptidyl-Dipeptidase A
Renin