Korean Circ J.  2003 Dec;33(12):1126-1133. 10.4070/kcj.2003.33.12.1126.

The Relationship between Serum Adiponectin, Essential Hypertension, LV Mass Index, and LV Diastolic Function

• Hong SJ
• Park CG
• Park JS
• Ahn JC
• Shin SH
• Park SM
• Lim HE
• Kim EJ
• Seo HS
• Oh DJ
• Ro YM
• Jang Y

• KMID: 2227243
• DOI: http://doi.org/10.4070/kcj.2003.33.12.1126

Abstract

BACKGROUND AND OBJECTIVES
Adiponectin is known for its anti-inflammatory and anti-atherogenic effects. The purpose of this study is to characterize the relationships among serum adiponectin, essential hypertension (EH), left ventricular mass index (LVMI), and LV diastolic function.
SUBJECTS AND METHODS
Serum adiponectin by RIA and body mass index were measured in 275 patients (M: F=137: 138). We calculated LVMI, E/A ratio, deceleration time (DT), and isovolumetric relaxation time (IVRT) by using echocardiograms.
RESULTS
The serum adiponectin level of the hypertensive group was significantly lower than that of the non-hypertensive group (9.9+/-9.8 ug/mL vs. 12.9+/-9.5 ug/mL, p<0.05). Plasma adiponectin was negatively correlated with LVMI (r=-0.329, p<0.001), BMI (r=-0.290, p<0.001), and IVRT (r=-0.485, p<0.05), but was positively correlated with E/A (r=+0.359, p<0.001).
CONCLUSION
These results suggest that a decrease in serum adiponectin is associated with an increase in blood pressure and BMI, progress of LVH, and decrease in LV diastolic function.

Keyword

Adiponectin; Hypertension; Left ventricular hypertrophy

MeSH Terms

Adiponectin*
Blood Pressure
Body Mass Index
Deceleration
Humans
Hypertension*
Hypertrophy, Left Ventricular
Plasma
Relaxation
Adiponectin