Diabetes Metab J.  2011 Dec;35(6):619-627. 10.4093/dmj.2011.35.6.619.

Cardiovascular Risk Assessment with Vascular Function, Carotid Atherosclerosis and the UKPDS Risk Engine in Korean Patients with Newly Diagnosed Type 2 Diabetes

• Seon CS
• Min KW
• Lee SY
• Nho KW
• Park SH
• Koo BK
• Han KA

• KMID: 2280730
• DOI: http://doi.org/10.4093/dmj.2011.35.6.619

Abstract

BACKGROUND
Patients with type 2 diabetes have an increased risk of cardiovascular disease. Few studies have evaluated the cardiovascular disease (CVD) risk simultaneously using the United Kingdom Prospective Diabetes Study (UKPDS) risk engine and non-invasive vascular tests in patients with newly diagnosed type 2 diabetes.
METHODS
Participants (n=380; aged 20 to 81 years) with newly diagnosed type 2 diabetes were free of clinical evidence of CVD. The 10-year coronary heart disease (CHD) and stroke risks were calculated for each patient using the UKPDS risk engine. Carotid intima media thickness (CIMT), flow mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AI) were measured. The correlations between the UKPDS risk engine and the non-invasive vascular tests were assessed using partial correlation analysis, after adjusting for age, and multiple regression analysis.
RESULTS
The mean 10-year CHD and 10-year stroke risks were 14.92+/-11.53% and 4.03+/-3.95%, respectively. The 10-year CHD risk correlated with CIMT (P<0.001), FMD (P=0.017), and PWV (P=0.35) after adjusting for age. The 10-year stroke risk correlated only with the mean CIMT (P<0.001) after adjusting for age. FMD correlated with age (P<0.01) and systolic blood pressure (P=0.09). CIMT correlated with age (P<0.01), HbA1c (P=0.05), and gender (P<0.01).
CONCLUSION
The CVD risk is increased at the onset of type 2 diabetes. CIMT, FMD, and PWV along with the UKPDS risk engine should be considered to evaluate cardiovascular disease risk in patients with newly diagnosed type 2 diabetes.

Keyword

Atherosclerosis; Cardiovascular risk; Diabetes mellitus, type 2; United Kingdom Prospective Diabetes Study risk engine; Vascular function

MeSH Terms

Aged
Atherosclerosis
Blood Pressure
Cardiovascular Diseases
Carotid Artery Diseases
Carotid Intima-Media Thickness
Coronary Disease
Diabetes Mellitus, Type 2
Great Britain
Humans
Pulse Wave Analysis
Risk Assessment
Stroke

Figure

• 

  Fig. 1 Plot of 10-year coronary heart disease (CHD) and 10-year stroke risks according to age. (A) 10-year CHD risk. (B) 10-year stroke risk.

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