Diabetes Metab J.  2013 Apr;37(2):140-148. 10.4093/dmj.2013.37.2.140.

Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes

• Pourghassem Gargari B
• Dehghan P
• Aliasgharzadeh A
• Asghari Jafar-abadi M

• KMID: 2280716
• DOI: http://doi.org/10.4093/dmj.2013.37.2.140

Abstract

BACKGROUND
The purpose of this study was to evaluate the effects of high performance inulin supplementation on blood glycemic control and antioxidant status in women with type 2 diabetes.
METHODS
In a randomized, triple-blind controlled trial, 49 females (fiber intake <30 g/day, 25RESULTS
At the end of the study period, there were significant decreases in fasting plasma glucose (8.47%), glycosylated hemoglobin (10.43%), and malondialdehyde (37.21%) levels and significant increases in total antioxidant capacity (18.82%) and superoxide dismutase activity (4.36%) in the inulin group when compared to the maltodextrin group (P<0.05). Changes in fasting insulin, homeostasis model assessment of insulin resistance, and catalase activity were not significant in the inulin group when compared with the maltodextrin group. Glutathione peroxidase activity remained unchanged in both groups.
CONCLUSION
Inulin supplementation may improve some glycemic and antioxidant indices and decrease malondialdehyde levels in women with type 2 diabetes. Further investigations are needed in order to confirm the positive effects that inulin may have on the glycemic and antioxidant indices of patients with type 2 diabetes.

Keyword

Antioxidants; Diabetes mellitus, type 2; Insulin resistance; Inulin; Malondialdehyde

MeSH Terms

Antioxidants
Catalase
Diabetes Mellitus, Type 2
Endocrinology
Fasting
Female
Glucose
Glutathione Peroxidase
Hemoglobin A, Glycosylated
Homeostasis
Humans
Insulin
Insulin Resistance
Inulin
Iran
Malondialdehyde
Plasma
Polysaccharides
Superoxide Dismutase
Antioxidants
Catalase
Glucose
Glutathione Peroxidase
Hemoglobin A, Glycosylated
Insulin
Inulin
Malondialdehyde
Polysaccharides
Superoxide Dismutase

Figure

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  Fig. 1 Study design.

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