Korean J Pediatr.  2007 Dec;50(12):1212-1216. 10.3345/kjp.2007.50.12.1212.

Maintenance dose of electrolyte free polyethylene glycol (PEG) 4000 in Korean children with chronic functional constipation

• Lee SH
• Bae SH

• KMID: 2279453
• DOI: http://doi.org/10.3345/kjp.2007.50.12.1212

Abstract

PURPOSE: To determine optimal maintenance dose and to evaluation the efficacy and safety of polyethylene glycol 4000 (PEG4000) in children with chronic functional constipation.
METHODS
This study enrolled 41 children with chronic functional constipation at the Konkuk university hospital August 2005, then June, 2007. Effective maintenance dose was designed as initial amount of PEG4000 that improved frequency, bowel movement, stool consistency for 2 months. Clinical outcome was analysed on the basis of defecation diary. Adverse effect was monitored clinically and biochemically.
RESULTS
As a whole group effective maintenance dose of PEG4000 was 0.550.16 g/kg/day (0.25-0.86). With respect to age, 3-5 years (0.600.15), 6-8 years (0.570.16), 9-13 years (0.440.14) (P=0.024). With respect to body weight, <30 kg (0.620.14), 30 kg (0.410.10) (P=0.001). One child comlained apigastric soreness on medication.
CONCLUSION
PEG4000 is effective and safe in children with chronic constipation. Initial maintenance dose of PEG4000 was 0.55 g/kg/day.

Keyword

Polyethylene glycol 4000; Maintenance dose; Constipation; Child

MeSH Terms

Body Weight
Child*
Constipation*
Defecation
Humans
Polyethylene Glycols*
Polyethylene*
Polyethylene
Polyethylene Glycols