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Effects of Novel Probiotics in a Murine Model of Irritable Bowel Syndrome

Chung HG, Min YW, Lee C, Hong SN, Won JY, Jang JA, Kim CH, Chang DK

BACKGROUND/AIMS: Dysbiosis is an important factor in the pathogenesis of irritable bowel syndrome (IBS). Several studies have reported promising results using probiotics for the treatment of IBS. This study evaluated...
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Clinical Features of Severely Constipated Children: Comparison of Infrequent Bowel Movement and Fecal Soiling Groups

Lee G, Son JS, Bae SH

PURPOSE: To compare the clinical features, diagnostic findings, and medications of children with infrequent bowel movements or fecal soiling. METHODS: This study enrolled 333 children (189 male; age range, 1 month...
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Bilateral Rotational S Flap Technique for Preventing Restenosis in Patients With Severe Circular Anal Stenosis: A Review of 2 Cases

Handaya Y, Sunardi M

Anal stenosis is a late hemorrhoidectomy complication. Sphincterotomy and various anoplasty techniques are used for treatment severe anal stenosis, such as the C flap, House flap, U flap, and rotational...
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Is stool frequency associated with the richness and community composition of gut microbiota?

Kwon HJ, Lim JH, Kang D, Lim S, Park SJ, Kim JH

BACKGROUND/AIMS: Recently, a number of studies have reported that the gut microbiota could contribute to human conditions, including obesity, inflammation, cancer development, and behavior. We hypothesized that the composition and...
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Nationwide Survey for Application of ROME IV Criteria and Clinical Practice for Functional Constipation in Children

Jang HJ, Chung JY, Seo JH, Moon JS, Choe BH, Shim JO

BACKGROUND: This study aimed to investigate the awareness and application of ROME IV criteria for functional constipation (FC) in real-world practices and assessed differences between pediatric gastroenterologists (PGs) and general...
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The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study

Benninga M, MENA Infant Constipation Study Group, Vandenplas Y

PURPOSE: To compare the effectiveness of the magnesium (Mg)-enriched formula vs. control formula in constipated infants. METHODS: An open-label, interventional, and the comparator-controlled study was conducted to evaluate the effectiveness of...
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High Prevalence of Slow Transit Constipation in Patients With Gastroparesis

Zikos TA, Kamal AN, Neshatian , Triadafilopoulos G, Clarke JO, Nandwani M, Nguyen LA

  • KMID: 2449099
  • J Neurogastroenterol Motil.
  • 2019 Apr;25(2):267-275.
  • doi: 10.5056/jnm18206
BACKGROUND/AIMS: Current evidence suggests the presence of motility or functional abnormalities in one area of the gastrointestinal tract increases the likelihood of abnormalities in others. However, the relationship of gastroparesis...
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Influence of Age and Body Mass Index on Total and Segmental Colonic Transit Times in Constipated Subjects

Bouchoucha M, Fysekidis , Rompteaux , Airinei G, Sabate JM, Benamouzig R

  • KMID: 2449098
  • J Neurogastroenterol Motil.
  • 2019 Apr;25(2):258-266.
  • doi: 10.5056/jnm18167
BACKGROUND/AIMS: Discordant data are found in the literature for the relationships between total and segmental colonic transit time (CTT) and demographic parameters. The aim of this study is to examine...
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High-resolution Anorectal Manometry in the Diagnosis of Functional Defecation Disorder in Patients With Functional Constipation: A Retrospective Cohort Study

Zhao Y, Ren X, Qiao W, Dong L, He S, Yin Y

  • KMID: 2449097
  • J Neurogastroenterol Motil.
  • 2019 Apr;25(2):250-257.
  • doi: 10.5056/jnm18032
BACKGROUND/AIMS: High-resolution anorectal manometry (HRAM) has been considered a first-line diagnostic tool for functional defecation disorder. However, clinical studies on HRAM used in constipation patients are very limited and few...
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Control of Motility in the Internal Anal Sphincter

Keef KD, Cobine CA

  • KMID: 2449091
  • J Neurogastroenterol Motil.
  • 2019 Apr;25(2):189-204.
  • doi: 10.5056/jnm18172
The internal anal sphincter (IAS) plays an important role in the maintenance of fecal continence since it generates tone and is responsible for > 70% of resting anal pressure. During...
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Usefulness of Personal Bowel Habits as a Predictive Factor for Inadequate Bowel Preparation for Colonoscopy: A Prospective Questionnaire-Based Observational Study

Paik N, Kim ER, Kim TJ, Hong SN, Chang DK, Kim YH

BACKGROUND/AIMS: The quality of bowel preparation is important for optimal colonoscopy. It is influenced by medical and personal factors. We aimed to evaluate the effect of bowel habit on the...
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Transabdominal Functional Magnetic Stimulation for the Treatment of Constipation in Brain-Injured Patients: A Randomized Controlled Trial

Yun YC, Yoon YS, Kim ES, Lee YJ, Lee JG, Jo WJ, Lee KJ

OBJECTIVE: To investigate the effects of the transabdominal functional magnetic stimulation (A-FMS) for constipation in stroke or brain-injured patients. METHODS: Twenty-four brain-injured patients (11 males and 13 females; median age, 65...
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Safety of subtotal or total colectomy with primary anastomosis compared to Hartmann procedure for left-sided colon cancer obstruction or perforation

Kim ED, Lee JK, Cho JK, Kim JM, Park JH, Kim JY, Jeong SH, Ju YT, Jeong CY, Jung EJ, Lee YJ, Hong SC, Kwag SJ

PURPOSE: Whether subtotal or total colectomy with primary anastomosis (PA) is safer than Hartmann procedure (HP) for left-sided colon cancer obstruction or perforation remains controversial. The purpose of this study...
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Role of a Micronized Purified Flavonoid Fraction as an Adjuvant Treatment to Rubber Band Ligation for the Treatment of Patients With Hemorrhoidal Disease: A Longitudinal Cohort Study

Caetano AC, Cunha C, Arroja B, Costa D, Rolanda C

PURPOSE: Nonsurgical treatment of hemorrhoidal disease (HD) includes medical and instrumental techniques. We aimed to compare the efficacy of the most frequently used nonsurgical strategies, either alone or in combination,...
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Predictors of Quality of Life and Social Support as a Mediator between Defecation Function and Quality of Life among Rectal Cancer Patients

Kim JR, Hwang SY

PURPOSE: To identify the factors influencing Quality of Life (QoL) in rectal cancer patients and to examine whether perceived social support mediates the relationship between defecation function and QoL. METHODS: Using self-report...
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A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation

Mori S, Tomita T, Fujimura K, Asano H, Ogawa T, Yamasaki T, Kondo T, Kono T, Tozawa K, Oshima T, Fukui H, Kimura T, Watari J, Miwa H

  • KMID: 2460486
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):563-575.
  • doi: 10.5056/jnm18194
BACKGROUND/AIMS: Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic...
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A Case of Anti-Le(bH) Antibody Identified in a Patient with Ulcerative Colitis

Hong J, Kim MS, Kim JS, Park H, Ko DH, Hwang SH, Oh HB

A 67-year-old man previously diagnosed with ulcerative colitis complained of difficulty in defecation and underwent balloon dilatation of rectum, but the procedure failed. The patient was transferred to a surgical...
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Differential Effects of Lactobacillus casei Strain Shirota on Patients With Constipation Regarding Stool Consistency in China

Chen S, Ou Y, Zhao L, Li Y, Qiao Z, Hao Y, Ren F

  • KMID: 2433508
  • J Neurogastroenterol Motil.
  • 2019 Jan;25(1):148-158.
  • doi: 10.5056/jnm17085
BACKGROUND/AIMS: Probiotics are expected to confer benefits on patients with constipation, but how probiotics act on constipated patients with variable stool consistencies remains unclear. We investigated the effect of Lactobacillus...
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Pelvic Floor Symptom Related Distress in Chronic Constipation Correlates With a Diagnosis of Irritable Bowel Syndrome With Constipation and Constipation Severity but Not Pelvic Floor Dyssynergia

Singh P, Seo Y, Ballou S, Ludwig A, Hirsch W, Rangan V, Iturrino J, Lembo A, Nee JW

  • KMID: 2433506
  • J Neurogastroenterol Motil.
  • 2019 Jan;25(1):129-136.
  • doi: 10.5056/jnm17139
BACKGROUND/AIMS: Although symptoms related to the pelvic floor, such as pelvic organ prolapse (POP) and lower urinary tract symptoms (LUTS), are common in patients with chronic constipation (CC), its impact...
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The Protective Effect of Melissa officinalis L. in Visceral Hypersensitivity in Rat Using 2 Models of Acid-induced Colitis and Stress-induced Irritable Bowel Syndrome: A Possible Role of Nitric Oxide Pathway

Dolatabadi F, Abdolghaffari AH, Farzaei MH, Baeeri M, Ziarani FS, Eslami M, Abdollahi , Rahimi R

  • KMID: 2417394
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):490-501.
  • doi: 10.5056/jnm17035
BACKGROUND/AIMS: The aim of present study is to estimate the effects of Melissa officinalis L. (MO) on visceral hypersensitivity (VH), defecation pattern and biochemical factors in 2 experimental models of...
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