Korean J Pediatr Hematol Oncol.  2003 Oct;10(2):269-276.

A Case of Idiopathic Hypereosinophilic Syndrome Treated Successfully with Hydroxyurea and Interferon alpha-2b

• Yang GH
• Park EY
• Jung HL
• Kim DS
• Shim JW
• Shim JY
• Park MS

Abstract

The idiopathic hypereosinophilic syndromes are rare hematologic disorders showing a wide spectrum of diseases with eosinophilia and associated organ damage. Three criteria for diagnosis include persistent eosinophilia of at least 1, 500 eosinophils/mm3 for longer than 6 months, or death before 6 months with signs and symptoms of hypereosinophilic disease; lack of evidence for parasitic, allergic or other known causes of eosinophilia; and signs and symptoms of organ involvement. We report a case of a 8 month-old male patient who had persistent marked eosinophilia reaching peak eosinophil count more than 100, 000/mm3, and organ dysfunction involving the bone marrow, heart, brain, lung and spleen. This patient, who did not respond to administration of prednisolone or hydroxyurea alone, has been treated successfully with hydroxyurea and interferon alpha-2b combination therapy.

Keyword

Idiopathic hypereosinophilic syndrome; Hydroxyurea; Interferon alpha-2b

MeSH Terms

Bone Marrow
Brain
Diagnosis
Eosinophilia
Eosinophils
Heart
Humans
Hydroxyurea*
Hypereosinophilic Syndrome*
Infant
Interferons*
Lung
Male
Prednisolone
Spleen
Hydroxyurea
Interferons
Prednisolone