Korean J Thorac Cardiovasc Surg.  2007 Apr;40(4):297-300.

Dysfunction of the Prosthetic Aortic Valve in Idiopathic Hypereosinophilic Syndrome: A case report

• Park CB
• Yoo DG
• Sung KW
• Jung SS
• Kang GH
• Kim CW

Abstract

Idiopathic hypereosinophilic syndrome is a rare systemic, leukoproliferative disorder characterized by eosinophil- mediated tissue injury causing multiple organ failure, including the heart. Cardiac involvement occurs in more than 75% of patients with hypereosinophilic syndrome. Cardiac manifestations include subendocardial fibrosis, thrombus leading to peripheral emboli, restrictive cardiomyopathy, and valvular dysfunction. It is more common in men than in women (9:1), and trends to present between the ages of 20 and 50 years. Presentation in childhood is unusual. We report for the first time a case of a 58-year-old man with idiopathic hypereosinophilic syndrome manifested by prosthetic aortic valve dysfunction that was successfully treated by steroid and hydroxyurea therapy after surgical valvular replacement.

Keyword

Hypereosinophilic syndrome, idiopathic; Aortic valve, surgery

MeSH Terms

Aortic Valve*
Cardiomyopathy, Restrictive
Female
Fibrosis
Heart
Humans
Hydroxyurea
Hypereosinophilic Syndrome*
Male
Middle Aged
Multiple Organ Failure
Thrombosis
Hydroxyurea