Korean J Otorhinolaryngol-Head Neck Surg.
2009 Jun;52(6):482-485. 10.3342/kjorl-hns.2009.52.6.482.
Activation of Lysozyme and Lactoferrin in Endolymphatic Duct of Rats
- Affiliations
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- 1Department of Otolaryngology, College of Medicine Konkuk University, Chungju, Korea. kkdin@kku.ac.kr
- 2Department of Family Medicine, College of Medicine Konkuk University, Chungju, Korea.
- 3Department of Neurosurgery, College of Medicine Konkuk University, Chungju, Korea.
- 4Konkuk University Chungju Hospital Research Institute of Clinical Medicine, Chungju, Korea.
- KMID: 2277062
- DOI: http://doi.org/10.3342/kjorl-hns.2009.52.6.482
Abstract
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BACKGROUND AND OBJECTIVES: Secretory activity, particularly of antibacterial agents such as lysozyme and lactoferrin, is an important aspect of the mucosal defense mechanism. The development of these agents may have a direct bearing on the susceptibility of the mucosa to infection. The antibacterial secretory enzymes such as lysozymes and lactoferrins are found in various mucosal tissues, and it has been suggested that these enzymes contribut to the defense against local mucosal infection. Specifically, lysozyme and lactoferrin are important components of innate immunity against pathogens at mucosal surfaces. The purpose of this study is to identify the distribution and expression of lysozyme, lactoferrin in endolymphatic duct of rat.
MATERIALS AND METHOD: Normal rats (129P3/J, 10 cases) were used for this study. The expression level and distribution of lysozyme mRNA were analyzed by RT-PCR and quantitative image analysis.
RESULTS
The expression of lysozyme and lactoferrin mRNA in endolymphatic ducts of rats was compared by quantitative image analysis. The results indicate that the relative expression of lysozyme mRNA resulted as 2.5 times greater than that of lactoferrin mRNA.
CONCLUSION
The distribution and expression of lysozyme and lactoferrin in the endolymphatic duct of rat were identified. The study suggests that innate immunity such as lysozyme and lactoferrin are important components of defense mechanisms along with mucociliary clearance. Additionally, the authors think that the activity of lysozymes is more effective than that of lactoferrin in the endolymphatic duct of rat.
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