J Korean Soc Virol.
1999 Jun;29(2):87-97.
Effect of Bovine and Human Lactoferrin on MA 104 Cell Infected with Human Rotavirus
- Affiliations
-
- 1School of Animal Life Science, College of Animal Husbandry, Konkuk University.
- 2Korea Research Institute of Bioscience and Biotechnology.
- 3Department of Microbiology, School of Medicine, Catholic University of Taegu-Hyosung.
Abstract
- It has long been known that lactoferrin prevents human beings from infection of virus. To prove this activity of lactoferrin, we evaluated the activities of different lactoferrins to an isolate human rotavirus K-21. Bovine lactoferrin inhibited infection of K-21 to MA-104 cell at the concentration of 25.9 microM whereas bovine hydrolysed lactoferrin prevented rotavirus infection at 103.8 microM. However human lactoferrin prevented infection of K-21 at the concentration of 217.5 microM. These data suggested that lactoferrin activity may be unaffected by the intestinal digestive enzymes and bovine lactoferrin is more active than human lactoferrin with respect to prevention of rotavirus infection.
