Chonnam Med J.  1996 Dec;32(2):107-120.

Expression of p53 Gene in the Endometrial Hyperplasia and Andenocarcinoma

Affiliations
  • 1Department of Pathology, Chonnam National University Medical School, Kwangju, Korea.

Abstract

We examined the expression of the p53 gene in eight cases of simple endometrial hyperplasia, four cases of complex hyperplasia, six cases of atypical hyperplasia and twenty four cases of adenocarcinoma which are included two cases of uterine serous carcinoma by using a monoclonal antibody, MAb 1801. We also analyzed the association between the expression of p53 gene and the risk factors, such as clinical stage, histologic grade and depth of myometrial invasion. No staining was detected in the atrophic and hyperplastic endometrium including atypical hyperplasia, whereas nuclear staining of cancer cells was observed in 13 (54.2%) of 24 endometrial adenocarcinomas. Of interest, two cases of uterine serous carcinoma showed strong nuclear staining. There was significant relationship between p53 immunostaining and clinical stage, histologic grade and depth of myometrial invasion. These results suggest that the expression of p53 gene is associated with not only carcinogenesis but also biological behavior of endometrial carcinoma.


MeSH Terms

Adenocarcinoma
Carcinogenesis
Endometrial Hyperplasia*
Endometrial Neoplasms
Endometrium
Female
Genes, p53*
Hyperplasia
Risk Factors
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