Effect of Gabexate Mesilate on Exocrine Secretion of Pancreas in Rats

Choi, Sung Kyu; Kim, Gi Tae; Park, Chang Hwan; Rew, Jong Sun; Kim, Sei Jong; Yoon, Chong Mann

Abstract

Gabexate mesilate is a synthetic compound of 417 daltons that is not antigenic and diffuse easily. Gabexate is a serine protease inhibitor, with effect on trypsin, kallikrein, plasmin and thrombin. To evaluate the effect of gabexate mesilate on exocrine pancreatic secreation in rat, the volume, bicarbonate and protein of pancreatic secretion were measured in basal and cholecytokinin(CCK) stimulated state with the administration of gabexate mesilate. The volume of pancreatic secretion was 20.1+/-1.1ul/30min in basal state, 17.1+/-1.6ul/30min after the infusion of gabexate mesilate, 58.9+/-3.9ul/30min in CCK stimulated state, 56.2+/-4ul/30min after the infusion of CCK and gabexate in order. There is no significant effect of gabezate mesilate on the volume of pancreatic secretion at the basal and CCK stimulated state. The amount of bicarbonate in pancreatic secretion was 30.1+/-1.3umol/30min in basal state, 29.6+/-1.6umol/30min after gabexate mesilate, 193.1+/-4.3umol/30min in CCK stimulated state, 185.9+/-6.7umol/30min after CCK and gabexate in order. There is no significant effect of gabexate mesilate on the amount of bicarbonate in pancreatic secretion. The amount of protein in pancreatic secretion was 39.8+/-1.2ug/30min in basal state and 30.1+/-1.3ug/30min after the infusion of gabexate mesilate. In CCK stimulated state, the amount of protein was 396.0+/-6.2ug/30min and 295.9+/-5.9ug/30min after the infusion of gabexate mesilate. At both basal and CCK stimulated state, gabexate mesilate significantly decreased the amount of protein in pancreatic secretion(p<0.05). In conclusion, gabexate mesilate was no effect on the volume and bicarbonate of pancreatic exocrine secretion, but decreased the amount of protein in basal and CCK stimulated state in rat.