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Novel Associations between Related Proteins and Cellular Effects of High-Density Lipoprotein

Choi S, Park YE, Cheon EJ, Kim KY, Kim M, Ann SJ, Noh HM, Lee J, Lee CJ, Lee ST, Lee C, Lee JE, Lee SH

BACKGROUND AND OBJECTIVES: Recent studies have examined the structure-function relationship of high-density lipoprotein (HDL). This study aimed to identify and rank HDL-associated proteins involved in several biological function of HDL. METHODS:...
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A Case of 47-Years-Old Female with Obstructive Jaundice and Weight Loss

Park PG, Kang H, Chung MJ, Park JY, Bang S, Park SW, Song SY, Lee HS

Serine protease inhibitor Kazal-type 1 (SPINK1) is a gene expressed from pancreatic acinar cell which its mutation is known to be associated with chronic pancreatitis (CP) and pancreatic cancer. We...
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Therapeutic potential of alpha-1 antitrypsin in human disease

Kim M, Cai Q, Oh Y

Alpha-1 antitrypsin (AAT), an alpha globulin glycoprotein, is a member of the serine protease inhibitor (serpin) superfamily. The clinical significance of AAT is highlighted by AAT deficiency. Genetic deficiency of...
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Allergic bronchopulmonary mycosis – pathophysiology, histology, diagnosis, and treatment

Asano K, Kamei K, Hebisawa A

Allergic bronchopulmonary mycosis (ABPM) develops mainly in patients with asthma or cystic fibrosis via types I and III hypersensitivity reactions to filamentous fungi. Aspergillus spp., especially Aspergillus fumigatus, is the...
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Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse

Lee MY, Kang JS, Go RE, Byun YS, Wi YJ, Hwang KA, Choi JH, Kim HC, Choi KC, Nam KH

Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha (TNF-α)...
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The Role of Genetic Mutation in the Pathogenesis of Pancreatitis

Paik WH, Jang DK, Lee JK

10–30% of patients with pancreatitis can be categorized as idiopathic pancreatitis, and some of them may be due to genetic alterations. Since hereditary pancreatitis develops from pediatric patients with symptoms...
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IL-32-induced Inflammatory Cytokines Are Selectively Suppressed by α1-antitrypsin in Mouse Bone Marrow Cells

Lee S, Choi DK, Kwak A, Kim S, Nguyen TT, Gil G, Kim E, Yoo KH, Kim IA, Lee Y, Jhun H, Chan ED, Bai X, Kim H, Kim YS, Kim S

The induction of interleukin (IL)-32 in bone marrow (BM) inflammation is crucial in graft versus host disease (GvHD) that is a common side effect of allogeneic BM transplantation. Clinical trials...
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Nafamostat mesilate promotes endothelium-dependent vasorelaxation via the Akt-eNOS dependent pathway

Choi S, Kwon HJ, Song HJ, Choi SW, Nagar H, Piao S, Jung SB, Jeon BH, Kim DW, Kim CS

Nafamostat mesilate (NM), a synthetic serine protease inhibitor, has anticoagulant and anti-inflammatory properties. The intracellular mediator and external anti-inflammatory external signal in the vascular wall have been reported to protect...
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Vacuolar Serine Protease Is a Major Allergen of Fusarium proliferatum and an IgE-Cross Reactive Pan-Fungal Allergen

Yeh CC, Tai HY, Chou H, Wu KG, Shen HD

PURPOSE: Fusarium species are among prevalent airborne fungi and causative agents of human respiratory atopic disorders. We previously identified a 36.5-kDa F. proliferatum component recognized by IgE antibodies in 9...
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iRhoms; Its Functions and Essential Roles

Lee MY, Nam KH, Choi KC

In Drosophila, rhomboid proteases are active cardinal regulators of epidermal growth factor receptor (EGFR) signaling pathway. iRhom1 and iRhom2, which are inactive homologs of rhomboid intramembrane serine proteases, are lacking...
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High Levels of Serum DPP-4 Activity Are Associated with Low Bone Mineral Density in Obese Postmenopausal Women

Kim SW, Cho EH

BACKGROUND: Dipeptidyl peptidase 4/CD26 (DPP-4) is a widely expressed cell surface serine protease. DPP-4 inhibitors, one of common anti-diabetic agents play a protective role in bone metabolism in recent studies....
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Allergenic Characterization of a Novel Allergen, Homologous to Chymotrypsin, from German Cockroach

Jeong KY, Son M, Lee JH, Hong CS, Park JW

PURPOSE: Cockroach feces are known to be rich in IgE-reactive components. Various protease allergens were identified by proteomic analysis of German cockroach fecal extract in a previous study. In this...
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Nafamostat Mesilate Inhibits TNF-alpha-Induced Vascular Endothelial Cell Dysfunction by Inhibiting Reactive Oxygen Species Production

Kang MW, Song HJ, Kang SK, Kim Y, Jung SB, Jee S, Moon JY, Suh KS, Lee SD, Jeon BH, Kim CS

Nafamostat mesilate (NM) is a serine protease inhibitor with anticoagulant and anti-inflammatory effects. NM has been used in Asia for anticoagulation during extracorporeal circulation in patients undergoing continuous renal replacement...
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Serine Proteases of Parasitic Helminths

Yang Y, Wen YJ, Cai YN, Vallee I, Boireau P, Liu MY, Cheng SP

Serine proteases form one of the most important families of enzymes and perform significant functions in a broad range of biological processes, such as intra- and extracellular protein metabolism, digestion,...
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Epidermal Proteinase-Activated Receptor-2 Expression is Increased in End-Stage Renal Disease Patients with Pruritus: A Pilot Study

Moon SJ, Kim HJ, Cho SB, Lee SH, Choi HY, Park HC, Ha SK

Uremic pruritus is a common problem in patients with end-stage renal disease (ESRD), but the underlying mechanisms are not yet fully understood. We aimed to investigate the association between severity...
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The Serine Protease Inhibitor, 4-(2-aminoethyl) Benzene Sulfonyl Fluoride Hydrochloride, Reduces Allergic Inflammation in a House Dust Mite Allergic Rhinitis Mouse Model

Kim BY, Park HR, Shin JH, Kim SW, Cho JH, Park YJ, Kim SW

PURPOSE: Serine protease inhibitors are involved in immune development, anti-inflammatory mechanisms, and tissue repair. In the present study, the serine protease inhibitor 4-(2-aminoethyl) benzene sulfonyl fluoride hydrochloride (AEBSF) was evaluated...
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The Use of Nafamostat Mesilate as an Anticoagulant during Continuous Renal Replacement Therapy for Children with a High Risk of Bleeding

Lee ST, Cho H

PURPOSE: Nafamostat mesilate (NM), a synthetic serine protease inhibitor, has been investigated as an anticoagulant for adult patients with a high risk of bleeding, who need chronic renal replacement therapy...
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Transcriptional Upregulation of Plasminogen Activator Inhibitor-1 in Rat Primary Astrocytes by a Proteasomal Inhibitor MG132

Cho KS, Kwon KJ, Jeon SJ, Joo SH, Kim KC, Cheong JH, Bahn GH, Kim HY, Han SH, Shin CY, Yang SI

  • KMID: 1502511
  • Biomol Ther.
  • 2013 Mar;21(2):107-113.
Plasminogen activator inhibitor-1 (PAI-1) is a member of serine protease inhibitor family, which regulates the activity of tissue plasminogen activator (tPA). In CNS, tPA/PAI-1 activity is involved in the regulation...
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Immunoresuscitation Effect on Hemorrhagic Shock-Induced Acute Lung Injury in Rats

Park SH, Lee MJ, Jo KH, Kim YG

  • KMID: 2333112
  • J Korean Soc Emerg Med.
  • 2012 Apr;23(2):270-278.
PURPOSE: Recent studies have indicated that cytokines and inflammatory responses are related to hemorrhagic shock-(HS) induced acute lung injury. Novel, synthetic, broad-acting serine protease inhibitors that protect a wide range...
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Effect of ulinastatin on the rocuronium-induced neuromuscular blockade

Kim MS, Park JW, Lim YH, Yoo BH, Yon JH, Kim DW

BACKGROUND: Ulinastatin is a glycoprotein derived from human urine and a serine protease inhibitor found in human urine and blood. Ulinastatin increases both liver blood flow and urine output. Rocuronium...
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