Korean J Obstet Gynecol.
2004 Oct;47(10):1949-1953.
Effect of Metformin Treatment and Insulin Resistance in Patients with Polycystic Ovary Syndrome
- Affiliations
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- 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
- 2Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Seoul, Korea.
- 3Department of Obstetrics and Gynecology, Seoul National University Boramae Hospital, Korea.
- 4Department of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, Korea.
- 5Department of Obstetrics and Gynecology, Pochon CHA University College of Medicine, Korea.
- 6Department of Obstetrics and Gynecology, Cheongju St. Mary Hospital, Cheongju, Korea.
Abstract
OBJECTIVE
This study was performed to investigate the effect of metformin treatment and insulin resistance in the patients with polycystic ovary syndrome.
METHODS
Twenty three patients with polycystic ovary syndrome were included at Seoul National University Hospital from September 2001 to September 2003. Metformin was administered at daily 1,500 mg for 3 months to these patients. Then restoration of regular menstruation or recovery of ovulation was evaluated and insulin resistance was compared between the responder and the non-responder before and after metformin treatment.
RESULTS
Eleven patients (47.8%) showed a significant improvement in menstrual or ovulation cyclicity whereas twelve patients had no change. There was no statistically significant difference in the insulin resistance between the responder and the non-responder before and after metformin treatment.
CONCLUSION
In non-obese patients with polycystic ovary syndrome, metformin treatment seems to be effective to improvement of menstrual or ovulation cyclicity irrespective of insulin resistance expressed as glucose-to- insulin ratio and HOMA.
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