Korean J Fertil Steril.  2001 Dec;28(4):255-264.

The Effect of Metformin Therapy on Clomiphene Citrate-resistant Polycystic Ovarian Syndrome Women

• Ko SH
• Lee SH

Abstract

OBJETIVE: This study was performed to investigate the effect of metformin therapy on ovulation induction & pregnancy rate in clomiphene citrate-resistant PCOS women. METHOD: This study used a randomized, single-blinded, case-controlled methods. Total study group consisted of 21 women who showed clomiphene citrate-resistant parttern on previous ovulation induction cycles. Patients of metformin group received metformin 500 mg three times daily, for 7 weeks. Control group received none. Metformin group was consisted of 10 women and control group was consisted of 11 women. Then clomiphene was administrated at daily 50 mg for 5 days to both groups. Clomiphene dosage was increased to daily 150 mg until ovulation was occurred. Before and After metformin treatment, blood samples for measurement of insulin, glucose, steroids were obtained.
RESULTS
In the metformin and control groups, 6 of 10 women (60%) and 2 of 11 women (18%) ovulated. And 4 of 10 women (40%) and 0 of 11 women (0%) conceived. Comparisons between the groups were significant.
CONCLUSION
In PCOS women who are resistant to CC, metformin use increased the ovulation rate and pregnancy rate from CC treatment, significantly.

Keyword

Metformin; Insulin resistance; Polycystic ovarian syndrome

MeSH Terms

Case-Control Studies
Clomiphene*
Female
Glucose
Humans
Insulin
Insulin Resistance
Metformin*
Ovulation
Ovulation Induction
Polycystic Ovary Syndrome*
Pregnancy Rate
Steroids
Clomiphene
Glucose
Insulin
Metformin
Steroids