A Study on the Leptin Concentrations in Maternal and Cord Blood

Lee, Hee Joong; Kim, Gi Hong; Rhu, Sang Woo; Park, Dong Choon; Kim, Jae Hoon; Kwon, Dong Jin; Kim, Sa Jin; Lew, Young Ok; Kim, Dae Hoon

Abstract

OBJECTIVE
In this study, We investigated the circulating level of leptin in the maternal and cord serum to estimate the effect of leptin on the fetal growth.
METHODS
In full-term pregnancy, right after delivery, we calculated the concentration of leptin in the maternal and cord serum by using an immunoassay. we studied the relation between these value, the maternal BMI at the time of delivery, the neonatal body weight.
RESULTS
At the time of delivery, mean concentration of maternal leptin and cord leptin showed 335.7 pg/ml and 118.3 pg/ml and there was no statistical significance between them. Mean concentration of matenal leptin has positive relation with maternal body weight. but not to neonatal weight. Mean concentration of cord serum leptin has a positive relation with neonatal weight. There was a correlation between the maternal BMI and the neonatal weight at the time of delivery. We evaluated the mean leptin level of neonates of two different sexes, that difference did not show a statistically significant level.
CONCLUSION
In this study, no correlation was found between concentration of maternal leptin and cord leptin. These data suggested that the cord serum leptin has a positive relation with fetal growth independantly, regardless of maternal leptin and maternal BMI.