Korean J Perinatol.  1999 Dec;10(4):472-477.

Correlation of Leptin Level between Maternal and Umbilical Cord Plasma in Normal Pregnancy and Preeclanpsia

• Lee JY
• Choi KY
• Bae DH

Abstract

OBJECTIVE
We investigated the effect of preeclampsia, birth weight, fetal sex, maternal body mass index(BMI) on cord blood leptin concentrations. This study is to test whether leptin would be increased in preeclampsia and to test cord leptin concentrations for correlation with maternal leptin concentrations. METHOD: Maternal blood samples were obtained from 56 normal pregnancies and 24 preeclampsia women prior to delivery. Umbilical cord blood were obtained from the all cases studied immediately after delivery. The total leptin levels were determined by radioimmunoassay.
RESULTS
Mean maternal leptin level was 16.4+/-6.4ng/ml in normal pregnancy and was 19.4+/-7.9 ng/ml in preeclampsia. Mean cord leptin level was 5.4+/- 3.4ng/ml in normal pregnancy and 4.6+/-3.2ng/ml in preecalmpsia. Mean cord blood leptin level in female fetus was 6.6+/-3.7ng/ml and 4.8+/-2.8ng/ml in male fetus.
CONCLUSION
This study shows that there are correlation with leptin level and fetal birth weight, body mass index, and fetal gender. Furthermore, physiologic role and mechanism of leptin of maternal serum and umbilical cord would be studied.

Keyword

Leptin; Preeclampsia; Birth weight; BMI(body mass index); Fetal sex

MeSH Terms

Birth Weight
Body Mass Index
Female
Fetal Blood
Fetus
Humans
Leptin*
Male
Plasma*
Pre-Eclampsia
Pregnancy*
Radioimmunoassay
Umbilical Cord*
Leptin