Korean J Obstet Gynecol.  2003 Sep;46(9):1781-1784.

An Unusual Relapse of Acute Lymphoblastic Leukemia in the Uterine Corpus

• Kwon JY
• Song MJ
• Choi WM
• Lee Y
• Rha JG
• Kim SP

Abstract

The relapse of leukemia is usually classified as hematologic relapse and extramedullary relapse. The most common sites of clinical extramedullary relapse are the central nervous systems (CNS) and gonads. However, the relapse in the uterus is very rare. We experienced a very unusual case of uterine relapse of acute lymphoblastic leukemia (ALL) after about a 6-year remission period. This female patient returned to our hospital with a two-month history of amenorrhea. Pelvic radiology confirmed an about 7 cm sized ill-defined ovoid mass in the uterus. There was no evidence of ALL relapse in the peripheral blood or CNS. The uterine biopsy showed diffused homogenous infiltration of numerous small round cells in uterine corpus, suggesting ALL relapse. The bone marrow study revealed 100% cellularity, most of which were lymphoblasts. Our patient received the bone marrow transplantation (BMT) and achieved the second complete remission (CR). Therefore, we here report our case with a brief review of literature.

Keyword

Acute lymphoblastic leukemia; Relapse; Uterine corpus

MeSH Terms

Amenorrhea
Biopsy
Bone Marrow
Bone Marrow Transplantation
Central Nervous System
Female
Gonads
Humans
Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Recurrence*
Uterus