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Anorexia Nervosa and Osteoporosis: Pathophysiology and Treatment

Steinman J, Shibli-Rahhal A

Anorexia nervosa (AN) affects 2.9 million people, many of whom experience bone loss and increased fracture risk. In this article, we review data on the underlying pathophysiology of AN-related osteoporosis...
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Human Immunodeficiency Virus Infection and the Endocrine System

Zaid D, Greenman Y

In the current era of effective antiretroviral therapies (ARTs), human immunodeficiency virus (HIV) infection became a chronic disorder that requires long term follow-up. Among other medical issues, these patients may...
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Recovery of Spermatogenesis Following Cancer Treatment with Cytotoxic Chemotherapy and Radiotherapy

Okada K, Fujisawa M

The survival rates of boys and men with cancer have increased due to advances in cancer treatments; however, maintenance of quality of life, including fertility preservation, remains a major issue....
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Intravenous Leiomyomatosis Extending from the Uterus to the Heart

Mohd Yusof M, Awang Ramli KA, Yahaya Z, Ghapar AK, Mohamed Dani N, Ismail H, Muhammad Nor MA, Leman H, Mohammed Y

We report a case of intravenous leiomyomatosis with right atrium extension through the left gonadal vein, left renal vein and inferior vena cava. The tumor moved in and out of...
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Amenorrhea and Menopause in Patients with Breast Cancer after Chemotherapy

Shin JJ, Choi YM, Jun JK, Lee KH, Kim TY, Han W, Im SA

PURPOSE: The probability of ovarian failure after cytotoxic chemotherapy in patients with breast cancer has not been well established in Korea. This study aimed to assess the rate of ovarian...
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Pubertal outcomes and sex of rearing of patients with ovotesticular disorder of sex development and mixed gonadal dysgenesis

Kim YM, Oh A, Kim KS, Yoo HW, Choi JH

PURPOSE: Patients with ovotesticular disorder of sex development (DSD) and mixed gonadal dysgenesis (MGD) usually present with asymmetric gonads and have wide phenotypic variations in internal and external genitalia. The...
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Primary Pelvic Peritoneal Yolk Sac Tumor in the Post-Pubertal Female: a Case Report with Literature Review

Kim M, Lee EJ, Hwang J, Hong SS, Chang YW, Oh E, Nam BD, Choi I, Kim JS

Yolk sac tumors are rare malignant germ cell neoplasms that usually arise from the gonads. Extragonadal yolk sac tumors (EGYSTs) frequently occur in the mediastinum in post-pubertal females. EGYSTs in...
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Male pseudohermaphroditism with os clitoris in three dogs

Kim K, Lee SH, Son CH, Park SI, Lee CM

Two American Cocker Spaniels and one Bichon Frise were presented to our veterinary teaching hospital with an enlarged clitoris. Diagnostic imaging showed that the structure was composed of bony material....
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Testosterone Is a Contraceptive and Should Not Be Used in Men Who Desire Fertility

Patel AS, Leong JY, Ramos L, Ramasamy R

Testosterone has a variety of functions and is commonly used in older men to treat symptoms of hypogonadism, such as decreased libido, decreased mood and erectile dysfunction. Despite its positive...
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Prevalence of CYP17A1 gene mutations in 17α-hydroxylase deficiency in the Chinese Han population

Wang M, Wang H, Zhao H, Li L, Liu M, Liu F, Meng F, Fan C

BACKGROUND: 17α-hydroxylase deficiency is a rare autosomal recessive disorder caused by mutations in the cytochrome P450 family 17 subfamily A member 1 gene. The major clinical presentation includes hypertension, hypokalemia,...
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Testicular microlithiasis in a boy with X-linked adrenal hypoplasia congenita

Serbis A, Tsinopoulou VR, Mouzaki K, Kotanidou , Giza S, Galli-Tsinopoulou A

X-linked adrenal hypoplasia congenita (AHC) is a rare disorder that usually presents clinically as adrenal insufficiency in early infancy. It is caused by mutations in the NR0B1 gene which is...
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Porcine intestinal lymphoid tissues synthesize estradiol

Park CJ, Kim H, Jin J, Barakat R, Lin PC, Choi JM, Ko CJ

Estradiol (17β-estradiol) is synthesized primarily in the gonads of both sexes and regulates the development and function of reproductive organs. Recently, we reported that intestinal lymphocyte homeostasis is regulated by...
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Fertility preservation in pediatric and young adult female cancer patients

Kim H, Kim H, Ku SY

As the 5-year survival rate increases up to 80% in pediatric cancer patients, the number of women patients with reduced gonadal function by chemotherapy and radiotherapy increases. The gonadal toxicity...
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Intracranial Germ Cell Tumor in the Molecular Era

Phi JH, Wang KC, Kim SK

Intracranial germ cell tumors (iGCTs) are a heterogeneous group of tumors with peculiar characteristics clearly distinguished from other brain tumors of neuroepithelial origin. Diverse histology, similarity to gonadal GCT, predilection...
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Multidisciplinary approach for treatment of primary hepatic choriocarcinoma in adult male patient

Ahn Y, Kim JH, Park CS, Kim TE, Hwang S, Lee SG

Choriocarcinoma is a rare malignant germ cell tumor and it usually occurs in the gonads (ovary or testis) and uterus. Primary hepatic choriocarcinoma (PHC) is a variant of choriocarcinoma featuring...
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Ovary and vaginal epithelium dynamics during the estrous cycle in Dasyprocta prymnolopha Wagler, 1831: ultrasound and cytological examinations

Carreiro A, Diniz JA, Souza JG, Araújo DV, Dias RF, Azerêdo L, Rocha EF, La Salles , Peña-Alfaro CE, Carvalho M, Illera MJ, Menezes DJ

The objective of the present study was to monitor and characterize morphological alterations in ovaries of agouti (Dasyprocta prymnolopha), reared in captivity, by using abdominal ultrasonography. All animals underwent daily...
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Evaluation of immunocontraceptive vaccine composed of gonadotropin-releasing hormone conjugated with granulocyte-macrophage colony-stimulating factor in male rats

Park BJ, Kim YH, Ahn HS, Han SH, Go HJ, Lee JB, Park SY, Song CS, Lee SW, Choi IS

Surgical castration performed to reduce male-associated problems results in pain and microbial infections in male animals. Therefore, immunocontraception, which is mediated by the animal's own antibodies against reproductive hormones, has...
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Retroperitoneal fibrosis-clinical presentation and outcome analysis from urological perspective

Jadhav KK, Kumar V, Punatar CB, Joshi VS, Sagade SN

PURPOSE: To study clinical presentation, laboratory results, imaging findings and treatment options and outcomes of retroperitoneal fibrosis (RPF). To determine whether it follows the same natural course and response to...
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The Examination of Ovarian Reserve in Premenopausal Patients with Hormone Receptor Positive Breast Cancer

Kim HA, Woo J, Choi HS, Lee SJ, Choi J, Park CS, Seong MK, Noh WC

The evaluation of menopausal status is an important subject in the field of treatment of hormone receptor positive breast cancer. According to the menopausal status, endocrine therapy should be categorized...
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Female with 46, XY karyotype

Jung EJ, Im DH, Park YH, Byun JM, Kim YN, Jeong DH, Sung MS, Kim KT, An HJ, Jung SJ, Lee KB

Disorders of sex development (DSD) are congenital conditions characterized by atypical development of chromosomal, gonadal, and phenotypic sex. 46, XY DSD can result from disorders of testicular development or disorders...
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