Korean J Obstet Gynecol.  2003 Jun;46(6):1104-1109.

The Changes of Superoxide Dismutase Isozymes in the Placenta of Patients with Preeclampsia

• Ahn TG
• Jung H
• Song CH
• Choi SJ
• Lee BR
• Han SJ

Abstract

OBJECTIVE
The aim of this article was investigated whether changes of superoxide dismutase isozymes in the placenta of patients with preeclampsia contribute to radical-induced tissue injury.
METHODS
The activities of antioxidant enzymes (superoxide dismutase (SOD), catalase, glutathione peroxidase (GSHPx)) and the contents of thiobarbituric acid reactive substance (TBARS) in the erythrocytes and in the placenta were assayed from 35 women with preclampsia and 35 normotensive pregnant women.
RESULTS
The superoxide dismutase (SOD) activities were significantly reduced in the erhtyrocytes and the placenta of patients with pre-eclampsia compared with normotensive pregnant women. The activity of catalase was increased in the erythrocytes of patients with preeclampsia but the statistically significant difference of catalase activity in the placenta and GSHPx activity in both erythrocytes and placenta were not observed. The contents of TBARS were increased significantly in the erythrocytes and placenta of patients with preeclampsia. In preeclamptic placenta, copper and zinc containing superoxide dismutase (CuZn-SOD) was decreased (3.9+/-0.5 vs 5.1+/-0.6 U/mg protein) whereas manganeus containing superoxide dismutase (Mn-SOD) was increased (2.0+/-0.3 vs 2.7+/-0.4 U/mg protein).
CONCLUSION
In these results, the decreased CuZn-SOD activity may some roles in increment of TBARS contents in pre-eclamptic placenta and decreased CuZn-SOD activity may be more prone to oxidative stress in the placenta.

Keyword

Pre-eclampsia; SOD isozyme; Placenta; Thiobarbituric acid

MeSH Terms

Catalase
Copper
Erythrocytes
Female
Glutathione Peroxidase
Humans
Isoenzymes*
Oxidative Stress
Placenta*
Pre-Eclampsia*
Pregnant Women
Superoxide Dismutase*
Superoxides*
Thiobarbituric Acid Reactive Substances
Zinc
Catalase
Copper
Glutathione Peroxidase
Isoenzymes
Superoxide Dismutase
Superoxides
Thiobarbituric Acid Reactive Substances
Zinc