Korean J Obstet Gynecol.  2005 Nov;48(11):2550-2557.

The maternal change of malondialdehye levels in plasma and superoxide dismutase levels in plasma and erythrocyte as biologic markers of oxidative stress in pregnancy with preeclampsia

• Park MC

Abstract

OBJECTIVES
To evaluate lipid peroxidation status and antioxidative systems in preeclamptic pregnancies by measuring plasma malondialdehyde (MDA) and plasma and erythrocyte superoxide dismutase (SOD) activities in women with or without preeclampsia
METHODS
I measured lipid peroxidation end product, malondialdehyde in plasma and free radical scavenging enzyme, superoxide dismutase in plasma and erythrocyte as biologic markers of oxidative stress. The comparison was made between the sixteen preeclamptic women and the fourteen normal pregnant controls. Data were analyzed statistically using Student's t-test.
RESULTS
Maternal plasma concentration of MDA was not significantly different in preeclampsia (46.95+/-12.26 nmole/mL) as compared with normotensive pregnancy (54.01+/-29.91 nmole/mL). And preeclamptic women had similar antioxidant enzyme SOD activity in plasma (0.083+/-0.043 U/mg protein) as compared with normotensive pregnancy (0.081+/-0.012 U/mg protein). But, preeclamptic women showed significantly (P=0.02) enhanced SOD activity in erythrocyte (2.323+/-0.574 U/mg protein) as compared with normotensive pregnancy (1.859+/-0.528 U/mg protein).
CONCLUSION
The finding in this study do not show that oxidative stress might be a pathogenetically relevant process causally contributing to the disease. Oxidative process seem to be counteracted by the enhanced activation of antioxidant enzyme.

Keyword

Preeclampsia; Oxidative stress; Malondialdehyde; Superoxide dismutase

MeSH Terms

Biomarkers*
Erythrocytes*
Female
Humans
Lipid Peroxidation
Malondialdehyde
Oxidative Stress*
Plasma*
Pre-Eclampsia*
Pregnancy*
Superoxide Dismutase*
Superoxides*
Malondialdehyde
Superoxide Dismutase
Superoxides