Korean J Obes.
2013 Mar;22(1):56-65.
Effects of Growth Hormone Treatment beyond the Body Fat Changes in GH-deficient Adults
- Affiliations
-
- 1Vascular Metabolism Research Lab, Yonsei University, College of Medicine, Korea. kkwook35@hanmail.net
- 2Endocrinology and Metabolism Department Internal Medicine, Yonsei University, College of Medicine, Korea.
- 3Division of Endocrinology and Metabolism, Department Internal Medicine, Hanyang University, College of Medicine, Korea. dongsun@hanyang.ac.kr
- 4Department Endocrinology and Metabolism MEA, Aarhus University Hospital, Denmark.
Abstract
- BACKGROUND
The mechanisms underlying the effects of growth hormone(GH) on fat metabolism in GH-deficient (GHD) patients are not fully understood. This study was to evaluate the effects of GH replacement before the body fat changes and their relevant parameters in GHD patients.
METHODS
In total, 14 (5 males and 9 females) GHD adults (mean 34.4 +/- 8.2 yr, BMI 23.1 +/- 1.0 kg/m2) received GH treatment for 12 weeks. Body composition by dual-energy X-ray absorptiometry and fasting serum analyses were assessed before and after treatment.
RESULTS
GH replacement did not affect body weight (60.9 +/- 3.0, vs. 60.3 +/- 3.3 kg, P = 0.30), body fat mass (19.7 +/- 1.5, vs. 18.4 +/- 1.8 kg, P = 0.10) or HOMA IR (1.65 +/- 0.3, vs. 1.94 +/- 0.4, P = 0.34). However, serum adiponectin and leptin levels were distinctly reduced after GH administration (6.86 +/- 1.2, vs. 5.51 +/- 0.8 mg/L, P = 0.03; 8.7 +/- 1.1, vs. 6.5 +/- 1.0 ng/mL, P < 0.01, respectively). Interestingly, correlations between body fat mass and adipokines were stronger (adiponectin, before r = -0.502, P = 0.07 vs. after r = -0.634, P = 0.02; leptin, before r = 0.378, P = 0.18 vs. after r = 0.711, P = 0.004) after GH administration.
CONCLUSION
After 12 weeks-GH replacement, the reductions in serum adiponectin and leptin levels without significant body fat changes and the stronger correlations between body fat mass and these adipokines are reflective of the metabolic effects of GH probably due to the amelioration of compensatory mechanism of adiponectin like GHRH to overcome GH deficiency and leptin resistance in GHD patients.
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