Korean J Med.  2014 Jun;86(6):774-780.

Hodgkin's Lymphoma after Autologous Hematopoietic Stem Cell Transplantation for Angioimmunoblastic T-cell Lymphoma

• Park SY
• Yu HM
• Kim J
• An SH
• Kim WY
• Hur M
• Lee HG

Abstract

Post-transplantation lymphoproliferative disorder (PTLD) is a serious complication that can develop after either solid organ or hematopoietic stem cell transplantation (HSCT). The incidence of Hodgkin's lymphoma (HL) ranges from 0.5-1.0% of PTLD after HSCT without T-cell depletion. Here, we report a case of HL-PTLD that occurred after autologous peripheral blood stem cell transplantation for an angioimmunoblastic T-cell lymphoma (AITL). A 36-year-old patient developed fever and chills with multiple lymphadenopathies at day 673 after auto-HSCT for AITL. Three months after the transplant, the patient developed fever with elevated plasma Epstein-Barr virus (EBV)-PCR values. The excisional biopsy revealed HL at Ann Arbor stage IIIB. A total of 8 cycles of chemotherapy with ABVD please define were performed, and the patient has remained disease-free. To our knowledge, this is first case report of HL-PTLD after auto-PBSCT in Korea.

Keyword

Lymphoproliferative disorder; Hodgkin disease; Hematopoietic stem cell transplantation; Epstein-Barr virus

MeSH Terms

Adult
Biopsy
Chills
Drug Therapy
Fever
Hematopoietic Stem Cell Transplantation*
Herpesvirus 4, Human
Hodgkin Disease*
Humans
Incidence
Korea
Lymphoma, T-Cell*
Lymphoproliferative Disorders
Peripheral Blood Stem Cell Transplantation
Plasma
T-Lymphocytes