Korean J Med.  2014 Sep;87(3):357-362. 10.3904/kjm.2014.87.3.357.

A Case of Prolonged Hypogammaglobulinemia after Rituximab-Containing Chemotherapy in a Patient with Lymphoma

• Noh HJ
• Gong BH
• Kim YS
• Jung YH
• Woo IS
• Han CW

• KMID: 2269250
• DOI: http://doi.org/10.3904/kjm.2014.87.3.357

Abstract

Rituximab, an anti-CD20 monoclonal antibody, is an effective target agent against the B lymphocytes in B-cell lymphoid malignancies and various lymphoproliferative diseases. Moreover, the toxicity of rituximab is less severe than that of conventional cytotoxic agents, which has promoted the widespread application of rituximab in the treatment of B-cell lymphoma. However, depletion of B lymphocytes by rituximab, which leads to secondary hypogammaglobulinemia, can cause deterioration of humoral immunity. Although immune reconstitution after hematopoietic stem cell transplantation is known to prevent prolonged hypogammaglobulinemia, very few cases of long-standing hypogammaglobulinemia have been reported. We report herein a case of prolonged hypogammaglobulinemia after rituximab-containing chemotherapy and splenectomy in a patient with non-Hodgkin's lymphoma and discuss the clinical significance and pathogenetic mechanism of this phenomenon with a literature review.

Keyword

Non-Hodgkin's lymphoma; Rituximab; IgG deficiency

MeSH Terms

Agammaglobulinemia*
B-Lymphocytes
Cytotoxins
Drug Therapy*
Hematopoietic Stem Cell Transplantation
Humans
IgG Deficiency
Immunity, Humoral
Lymphoma*
Lymphoma, B-Cell
Lymphoma, Non-Hodgkin
Splenectomy
Rituximab
Cytotoxins