Korean J Nutr.  2010 Apr;43(2):114-122. 10.4163/kjn.2010.43.2.114.

Iron Status According to Serum Selenium Concentration and Physique in Young Female Adults

• Lee O
• Chung Y
• Moon J

• KMID: 2267975
• DOI: http://doi.org/10.4163/kjn.2010.43.2.114

Abstract

Se and Fe are trace minerals acting as antioxidant scavenging free radicals. Iron deficiency is the most frequently reported nutritional deficiency in females. Body iron status are known to be dependent not only upon dietary iron intake, but also upon micro-mineral nutrition and obesity. Antioxidants such as selenium are reported to play an important role on the regulation of erythropoiesis by protecting RBC membrane from antioxidative damage. In this study, iron status in young females and its relationships with selenium status and physique were examined. Serum selenium and iron concentrations were measured by HANARO research reactor using neutron activation analysis method (NAA-method). The proportion with iron deficiency and anemia were 27.1% and 8.6%, respectively in young females, but the proportion with iron deficient anemia was 1.4%. The mean serum selenium level was 12.0 microgram/dL and in normal range in the young women. The study participants were tertiled according to BMI and serum selenium levels. Serum ferritin and iron levels inclined with increasing BMI tertiles. Serum iron and RBC count were higher in middle selenium group than low selenium group. Individuals had significantly lower hematocrit level in the lowest tertile for their serum selenium levels compared with the highest tertile. The serum ferritin level was predicted 25% by BMI and RBC count 26.2% by the serum selenium level and body fat%. In conclusion, this study shows that body iron status in young adult females are influenced by obesity and body selenium status.

Keyword

iron; obesity; physique; serum selenium; iron status

MeSH Terms

Adult
Anemia
Antioxidants
Erythropoiesis
Female
Ferritins
Free Radicals
Hematocrit
Humans
Iron
Iron, Dietary
Malnutrition
Membranes
Minerals
Neutron Activation Analysis
Obesity
Reference Values
Selenium
Young Adult
Antioxidants
Ferritins
Free Radicals
Iron
Iron, Dietary
Minerals
Selenium

Reference

1. Cusick SE, Mei Z, Freedman DS, Looker AC, Ogden CL, Gunter E, Cogswell ME. Unexplained decline in the prevalence of anemia among US children and women between 1988-1994 and 1999-2002. Am J Clin Nutr. 2008. 88(6):1611–1617.

2. Cogswell ME, Looker AC, Pfeiffer CM, James D, Cook JD, Lacher DA, Beard JL, Lynch SR, Grummer-Strawn LM. Assessment of iron deficiency in US preschool children and nonpregnant females of childbearing age: National Helath and Nutrition examination survey 2003-2006. Am J Clin Nutr. 2009. 89:1334–1342.

3. Stoltzfus RJ. Iron deficiency: global prevalence and consequences. Food Nutr Bull. 2003. 24:suppl. 99–103.

4. Eftekhari MH, Eshraghian MR, Mozaffari-Khosravi H, Saadat N, Shidfar F. Effect of iron repletion and correction of iron deficiency on thyroid function in iron-deficient Iranian adolescent girls. Pak J Biol Sci. 2007. 10(2):255–260.

5. Korean Centers for Disease Control and Prevention. The fourth Korea National Health and Nutrition Examination Survey (KNHANES IV). 2007. Seoul:

6. Semba RD, Ricks MO, Ferrucci L, Xue QL, Guralnik JM, Fried LP. Low serum selenium is associaed with anemia among older adults in the United States. Eur J Clin Nutr. 2009. 63:93–99.

7. Van Nhien N, Yabutani T, Khan NC, Khanh le NB, Ninh NX, Chung le TK, Motonaka J, Nakaya Y. Association of low serum selenium with anemia among adolescent girls living in rural Vietnam. Nutrition. 2009. 25(1):6–10.

8. Fontaine M, Valli VE, Young LG. Studies on vitamin E and selenium deficiency in young pigs. III Effects on kinetics of erythrocyte production and destruction. Can J Comp Med. 1977. 41:57–63.

9. Bates CJ, Thane CW, Prentice A, Delves HT. Selenium status and its correlates in a British National Diet and Nutrition Survey: young people aged 4-18y. Eur J Clin Nutr. 2002. 56:873–881.

10. WHO. Obesity: Preventing and managing the global epidemic report of a WHO consultation on obesity. 1997. 7–16.

11. Nieman DC. Exercise testing and prescription: A health-related approach. 1999. 4th ed. Mountain View, CA: Mayfield.

12. Tortora GI, Grabowski SR. Principles of anatomy and physiology. 2000. New York: Wiley & sons Inc..

13. Centers for Disease Control and Prevention. Recommendation to prevent and control iron deficiency in the Unites States. MMWR Morb Mortal Wkly Rep. 1998. 47:1–29.

14. Looker AC, Dullman PR, Carroll MD, Gunter EW, Johnson CL. Prevalence of iron deficiency in the United States. J Am Med Assoc. 1997. 277:973–976.

15. Binkin NJ, Yip R. Hercberg S, Galan P, Dupin H, editors. When is anemia screening of value in detecting iron deficiency? Recent Knowledge on Iron and Folate Deficiencies in the World. 1990. Paris, France: Colloq INSERM;137–146.

16. U.S. Preventive Services Task Force. Office of Disease Prevention and Health Promotion. Screening for iron deficiency anemia-including iron prophylaxis. Guide to Clinical Preventive Services. 1996. 2nd ed. Washington DC, US: Department of Health and Human Services.

17. Mei Z, Cogswell ME, Parvanta I, Lynch S, Beard JL, Stoltzfus RJ, Grummer-Strawn LM. Hemoglobin and ferritin are currently are the most efficient indicators of population response to iron interventions: an analysis of nine randomized controlled trials. J Nutr. 2005. 135:1974–1998.

18. Cook JD, Skikne BS, Lynch SR, Reusser ME. Estimates of iron deficiency in the US population. Blood. 1986. 68:726–731.

19. Ahmed F, Coyne T, Dobson A, McClintock C. Iron status among Australian adults: findings of a population based study in Queensland, Australia. Asia Pac J Clin Nutr. 2008. 17(1):40–47.

20. Lee O, Moon J, Chung Y. The relationship between serum selenium levels and lipid profiles in adult women. J Nutr Sci Vitaminol (Tokyo). 2003. 49(6):397–404.

21. Kivela SL, Maenpaa P, Nissinen A, Alfthan G, Punsar S, Enlund H, Puska P. Vitamin A, vitamin E, and selenium status in an aged Finnish male population. Int J Vitam Nutr Res. 1989. 59(4):373–380.

22. Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. 2000. Washington DC: National Academy Press;284–324.

23. Tietz NW. Test book of clinical chemistry. 1986. WB Saunders Co.;1845.

24. Varo P, Alfthan G, Ekholm P, Aro A, Koivistoinen P. Selenium intake and serum selenium in Finland: effects of soil fertilization with selenium. Am J Clin Nutr. 1988. 48(2):324–329.

25. Bleys J, Navas-Acien A, Guallar E. Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. Arch Intern Med. 2008. 169(4):404–410.

26. Kvicala J, Zamrazil V, Cerovska J, Bednar J, Janda J. Evaluation of selenium supply and status of inhabitants in three selected rural and urban regions of Czech Republic. Biol Trace Elem Res. 1995. 47(1-3):365–375.

27. Korunova V, Skodova Z, Dedina J, Valenta Z, Parizek J, Pisa Z, Styblo M. Serum selenium in adult Czechoslovak (central Bohemia) population. Biol Trace Elem Res. 1993. 37(2-3):91–99.

28. Wolters M, Hermann S, Golf S, Katz N, Guallar AH. Selenium and antioxidant vitamin status of elderly German women. Eur J Clin Nutr. 2006. 60:85–91.

29. Matsuda A, Kimura M, Itokawa Y. Selenium level and gluthathione peroxidase activity in plasma, erythrocytes and platelets of healthy Japanese volunteers. J Nutr Sci Vitaminol (Tokyo). 1997. 43(5):497–504.

30. Hampel G, Schaller KH, Rosenmüller M, Oefele C. Selenium deficiency as contributing factor to anemia and thrombocytopenia in dialysis patients. Life Support Syst. 1985. 3(S1):36–40.

31. van Lettow N, West CE, van der Meer JWM, Wieringa FT, Semba RD. Low plasma selenium concentration, high plasma human immunodeficieny virus load and high interleukin-6 concentration are risk factors associated with anemia in adults presenting with pulmonary tuberculosis in zomba district, Malawi. Eur J Clin Nutr. 2005. 59:526–532.

32. Van Nhien N, Khan NC, Yabutani T, Ninh NX, Chung le TK, Motonaka J, Nakaya Y. Relationship of low serum selenium to anemia among primary school children living in rural Vietnam. J Nutr Sci Vitaminol (Tokyo). 2008. 54(6):454–459.

33. Gürgöze MK, Olçücü A, Aygün AD, Taskin E, Kiliç M. Serum and hair levels of zinc, selenium, iron, and copper in children with iron-deficiency anemia. Biol Trace Elem Res. 2006. 111(1-3):23–29.

34. Nagababu E, Chrest FJ, Rifkind JM. Hydrogen-peroxide induced heme degradation in red blood cells: the protective roles of catalase and gluthathione peroxidase. Biochem Biophys Acta. 2003. 1620:211–217.

35. McPhail DB, Sibbald AM. The role of free radicals in brassica induced anemia of sheep: an ESR spin trapping study. Free Radic Res Commun. 1992. 16:277–284.

36. Kaushal N, Hegde SN, Gandhi UH, Paulson RF, Prabhu KS. Selenium status and erythropoiesis in mice. FASEB J. 2009. 23:728.5.

37. Matsumoto K, Inagaki T, Hirunuma R, Enomoto S, Endo K. Contents and uptake rates of Mn, Fe, Co, Zn, and Se in Se-deficient rat liver cell fractions. Anal Sci. 2001. 17(5):587–591.

38. Matsumoto K, Terada S, Ariyoshi M, Okajo A, Hisamatsu A, Ui I, Endo K. The effect of long-running severe selenium-deficiency on the amount of iron and zinc in the organs of rats. Molecules. 2009. 14(11):4440–4453.

39. Mostert V, Hill KE, Burk RF. Loss of activity of the selenoenzyme thioredoxin reductase causesinduction of hepatic hem oyygenase-1. FERS Lett. 2003. 541:85–88.