Korean J Med.  2012 Mar;82(3):341-346.

Protease Inhibitor Treatment of Disseminated Intravascular Coagulation Associated with Aortic Dissection

• Ko SM
• Kim N
• Kim C
• Cho JH
• Lee EY
• Huh K
• Kim DK

Abstract

Disseminated intravascular coagulation (DIC) is a rare complication of aortic dissection. We report an unusual case of a 64-year-old woman with DIC associated with chronic aortic dissection who developed catastrophic intracranial hemorrhage. Computed tomography (CT) revealed partially thrombosed false lumen in the chronic dissected aneurysm of the thoracoabdominal aorta, which remained after surgery for acute type A aortic dissection. The laboratory profile showed features of DIC, including thrombocytopenia, hypofibrinogenemia, and increased D-dimer levels. Bleeding diathesis, including ecchymosis and coagulopathy, showed improvement following treatment with protease inhibitors (nafamostat and camostat).

Keyword

Aortic dissection; Disseminated intravascular coagulation; Protease inhibitor; Nafamostat mesilate; Heparin

MeSH Terms

Aneurysm
Aorta
Dacarbazine
Disease Susceptibility
Disseminated Intravascular Coagulation
Ecchymosis
Female
Fibrin Fibrinogen Degradation Products
Guanidines
Hemorrhage
Heparin
Humans
Intracranial Hemorrhages
Middle Aged
Protease Inhibitors
Thrombocytopenia
Dacarbazine
Fibrin Fibrinogen Degradation Products
Guanidines
Heparin
Protease Inhibitors