Korean J Med.  2012 Sep;83(3):385-389.

A Case of Primary Effusion Lymphoma in a Patient with Chronic Kidney Disease

• Kim M
• Han S
• Yu JR
• Jeong WS
• Kim HW
• Lee J
• Hyun CL

Abstract

Human herpes virus-8 (HHV-8)-negative primary effusion lymphoma (PEL) is frequently observed in patients with chronic liver disease. We describe herein a case of PEL in a patient with chronic kidney disease. A 59-year-old woman presented with dyspnea. The patient had a history of uncontrolled pleural effusion. The pleural effusion revealed a malignant cell-dominant exudate. Serological tests were negative for human immunodeficiency virus (HIV). Initial chest and abdomen computed tomography showed bilateral pleural effusion; however, no evidence of a tumor mass or lymph node enlargement was found. A malignant lymphoma of diffuse large B-cell type was confirmed by pleural fluid cytology. Immunohistochemical staining of malignant cells was negative for HHV-8. She was treated with rituximab and CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone) chemotherapy. We report a case of PEL in a patient with chronic kidney disease that may be a plausible predisposing factor for HHV-8-negative PEL.

Keyword

Chemotherapy; Diffuse large B cell lymphoma; Primary effusion lymphoma

MeSH Terms

Abdomen
Antibodies, Monoclonal, Murine-Derived
B-Lymphocytes
Doxorubicin
Dyspnea
Exudates and Transudates
Female
Herpesvirus 8, Human
HIV
Humans
Liver Diseases
Lymph Nodes
Lymphoma
Lymphoma, Primary Effusion
Middle Aged
Pleural Effusion
Renal Insufficiency, Chronic
Serologic Tests
Thorax
Vincristine
Rituximab
Antibodies, Monoclonal, Murine-Derived
Doxorubicin
Vincristine