Allergy Asthma Respir Dis.  2013 Sep;1(3):211-215. 10.4168/aard.2013.1.3.211.

Vitamin D insufficiency is associated with food sensitization in children under 2 years with atopic dermatitis

• Baek JU
• Hwangbo JW
• Lee HR
• Lee SY

• KMID: 2262962
• DOI: http://doi.org/10.4168/aard.2013.1.3.211

Abstract

PURPOSE
Vitamin D levels are known to be associated with development of allergic diseases. However, existing data are controversial. The aim of this study was to investigate whether vitamin D levels are associated with food sensitization (FS) in young children with atopic dermatitis (AD).
METHODS
We performed a medical record review of all patients under 2 years presenting to pediatric allergic clinic in Hallym University Sacred Heart Hospital for atopic dermatitis between March 1, 2012 and February 28, 2013. Serum 25-hydroxyvitamin D (25(OH)D)levels and six specific immunoglobulin E (IgE) to common food allergens were measured in 132 young children with AD. We defined vitamin D insufficiency was 25(OH)D <30 ng/mL, and FS as specific IgE > or =0.35 IU/mL to any of six common food allergens. Associations between serum 25(OH)D levels and FS were examined by using multiple logistic regression, adjusting for potential risk and confounding factors.
RESULTS
The mean age was 10.1 months. Among the 132 children with AD, 65.9% had FS. In this group, there was a negative correlation between 25(OH)D levels and serum eosinophil percentage (correlation coefficient [r]=-0.335, P<0.01), but not correlated with serum total IgE levels. Children with vitamin D insufficiency were more likely to have FS (adjusted odds ratio, 17.1; 95% confidence interval, 1.36 to 215; P=0.028) than those with adequate vitamin D levels.
CONCLUSION
Vitamin D insufficiency is associated with FS in young children with AD. Further research is needed to confirm these findings.

Keyword

Vitamin D; Food; Sensitization; Dermatitis; Atopic

MeSH Terms

Allergens
Child
Dermatitis
Dermatitis, Atopic
Eosinophils
Heart
Humans
Immunoglobulin E
Immunoglobulins
Logistic Models
Medical Records
Odds Ratio
Vitamin D
Vitamins
Allergens
Immunoglobulin E
Immunoglobulins
Vitamin D
Vitamins

Figure

• 

  Fig. 1 Egg white was most common food allergen that showed food sensitization.

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