Allergy Asthma Respir Dis.  2013 Jun;1(2):123-128. 10.4168/aard.2013.1.2.123.

Relationship between serum total IgE, specific IgE, and peripheral blood eosinophil count according to specific allergic diseases

Affiliations
  • 1Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea. chsh0414@naver.com

Abstract

PURPOSE
Elevated IgE, and blood eosinophil count are considered the hallmarks of allergic diseases, while the levels of those parameters are shared with normal population. This study is aimed to investigate the relationship between those factor and clinical value according to specific allergic diseases.
METHODS
We reviewed medical records of 946 patients with allergic diseases who had taken the allergy tests from 2001 to 2010. The effects of age, sex, specific diagnoses of diseases, such as atopic dermatitis (AD), allergic rhinitis (AR), bronchial asthma (BA), urticarial on allergy tests were assessed.
RESULTS
In contrast to those of total eosinophil counts, there was the trend of increasing IgE value with the age in children with allergic diseases. The titer of total IgE and eosinophil count were higher than those of control group of patients with acute urticaria. There was the positive relation between total IgE and eosinophil count in patients with allergic diseases. The positive predictive value and negative predictive value of total IgE for specific IgE were higher than those of total eoshinophil count.
CONCLUSION
There were the positive relation of total IgE and total eosinophil count in allergic diseases and the higher value of those compared with the control in this study. These values over a certain level have a positive predictive value of serum specific IgE and help us to determine whether we should test the serum specific IgE in patients with allergic diseases.

Keyword

Serum total IgE; Specific IgE; Blood eosinophil; Allergic diseases

MeSH Terms

Asthma
Child
Dermatitis, Atopic
Eosinophils
Humans
Hypersensitivity
Immunoglobulin E
Medical Records
Rhinitis
Rhinitis, Allergic, Perennial
Urticaria
Immunoglobulin E
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