Allergy Asthma Respir Dis.  2013 Jun;1(2):123-128. 10.4168/aard.2013.1.2.123.

Relationship between serum total IgE, specific IgE, and peripheral blood eosinophil count according to specific allergic diseases

  • 1Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea.


Elevated IgE, and blood eosinophil count are considered the hallmarks of allergic diseases, while the levels of those parameters are shared with normal population. This study is aimed to investigate the relationship between those factor and clinical value according to specific allergic diseases.
We reviewed medical records of 946 patients with allergic diseases who had taken the allergy tests from 2001 to 2010. The effects of age, sex, specific diagnoses of diseases, such as atopic dermatitis (AD), allergic rhinitis (AR), bronchial asthma (BA), urticarial on allergy tests were assessed.
In contrast to those of total eosinophil counts, there was the trend of increasing IgE value with the age in children with allergic diseases. The titer of total IgE and eosinophil count were higher than those of control group of patients with acute urticaria. There was the positive relation between total IgE and eosinophil count in patients with allergic diseases. The positive predictive value and negative predictive value of total IgE for specific IgE were higher than those of total eoshinophil count.
There were the positive relation of total IgE and total eosinophil count in allergic diseases and the higher value of those compared with the control in this study. These values over a certain level have a positive predictive value of serum specific IgE and help us to determine whether we should test the serum specific IgE in patients with allergic diseases.


Serum total IgE; Specific IgE; Blood eosinophil; Allergic diseases

MeSH Terms

Dermatitis, Atopic
Immunoglobulin E
Medical Records
Rhinitis, Allergic, Perennial
Immunoglobulin E


  • Fig. 1 (A, B) The comparision of serum total immunoglobulin E (IgE) concentrations and total eosinophil count among different age groups. The analysis after log-transformation followed by backtransformation.

  • Fig. 2 The relation of serum total immunoglobulin E (IgE) concentration and total eosinphil count. The significant positive correlation in atopic dermatitis (A), allergic rhinitis (B), and bronchial asthma (C), in contrast to that of urticaria (D).

  • Fig. 3 The value of serum total immunoglobulin E (IgE) concentrations and total eosinophil counts according to the alternate scoring method (ASM) score. The serum total IgE concentrations (A) and total eosinophil counts (B) in ASM score 2-6 group were significantly higher those in ASM score 0-1 group.

  • Fig. 4 Receiver operator characteristic curve (ROC) curve of serum total immunoglobulin E (IgE) concentration (A), and ROC curve of total eosinophil count (B).

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