Allergy Asthma Immunol Res.  2014 May;6(3):208-215. 10.4168/aair.2014.6.3.208.

Efficacy of Probiotic Therapy on Atopic Dermatitis in Children: A Randomized, Double-blind, Placebo-controlled Trial

Affiliations
  • 1Pediatric Allergy and Respiratory Center, Department of Pediatrics, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. bypyun@schmc.ac.kr

Abstract

PURPOSE
To evaluate a therapeutic efficacy of probiotics mixture (probiotics) in the treatment of children with mild-to-moderate atopic dermatitis (AD).
METHODS
Randomized, double-blind, placebo-controlled, parallel trial with a washout period of 2 weeks and an intervention period for 6 weeks, conducted from November 2010 to October 2011. One hundred children with mild to moderate AD (2-9 years old) were randomly allocated to the probiotics (Lactobacilluss casei, Lactobacillus rhamnosus, Lactobacillus plantarum, and Bifidobacterium lactis) or placebo groups. The assessment of efficacy was based on the change in eczema area severity index (EASI), visual analogue scale for pruritus (VASP), fecal cell counts of each strains (log10[cell counts/g stool]), and serum cytokine levels (Interleukin-4 [IL-4]; IL-10; Tumor necrosis factor alpha, [TNF-alpha]) in weeks 0 and 6.
RESULTS
Demographics and baseline characteristics at the week 0 were not significantly different between the 2 groups. The significant increments in fecal-cell counts were observed in the probiotcs group at week 6 (P=0.00), while the cytokine levels between the 2 groups were not significantly different in week 6 (IL-4, P=0.50; IL-10, P=0.58; TNF-alpha, P=0.82). The probiotics significantly improved clinical severity after 6 weeks' intervention of probiotics; however, the placebo group also showed significant improvement (EASI; P=0.00, VASP; P=0.00).
CONCLUSIONS
Our findings showed that probiotics successfully colonized in the intestine after 6 weeks' intervention; nevertheless, we could not find an additional therapeutic or immunomodulatory effects on the treatment of AD. Further long-term studies will be necessary to clarify the therapeutic efficacy of probiotics.

Keyword

Atopic dermatitis; cytokines; placebo-controlled trial; probiotics; Randomized Controlled Trial

MeSH Terms

Bifidobacterium
Cell Count
Child*
Colon
Cytokines
Demography
Dermatitis, Atopic*
Eczema
Humans
Interleukin-10
Intestines
Lactobacillus plantarum
Lactobacillus rhamnosus
Probiotics*
Pruritus
Tumor Necrosis Factor-alpha
Cytokines
Interleukin-10
Tumor Necrosis Factor-alpha

Figure

  • Fig. 1 Overview of the study design.

  • Fig. 2 Serum cytokine levels in the probiotics and placebo groups in weeks 0 and 6. (A) Serum IL-4 levels were similar in both groups in weeks 0 (P=0.30) and 6 (P=0.53). No significant difference in serum IL-4 levels was observed in weeks 0 and 6 in either the probiotics (P=0.73) or control (P=0.16) groups. (B) Serum IL-10 levels were similar in both groups in weeks 0 (P=0.84) and 6 (P=0.58). IL-10 levels were significantly decreased in 6 weeks, relative to baseline in the probiotics (P=0.03) and control (P=0.04) groups. (C) Serum TNF-α levels were similar in both groups in weeks 0 (P=0.47) and 6 (P=0.82). TNF-α levels were significantly increased in 6 weeks relative to baseline in the probiotics (P<0.01) and control (P<0.01) groups.


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Ann Dermatol. 2015;27(4):355-363.    doi: 10.5021/ad.2015.27.4.355.

Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived Extracellular Vesicles
Min-Hye Kim, Seng Jin Choi, Hyun-Il Choi, Jun-Pyo Choi, Han-Ki Park, Eun Kyoung Kim, Min-Jeong Kim, Byoung Seok Moon, Taek-ki Min, Mina Rho, Young-Joo Cho, Sanghwa Yang, Yoon-Keun Kim, You-Young Kim, Bok Yang Pyun
Allergy Asthma Immunol Res. 2018;10(5):516-532.    doi: 10.4168/aair.2018.10.5.516.

Probiotics as a Potential Immunomodulating Pharmabiotics in Allergic Diseases: Current Status and Future Prospects
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Allergy Asthma Immunol Res. 2018;10(6):575-590.    doi: 10.4168/aair.2018.10.6.575.


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