J Vet Sci.  2016 Dec;17(4):549-554. 10.4142/jvs.2016.17.4.549.

Effects of cetirizine in dogs with chronic atopic dermatitis: a randomized, double blind, placebo-controlled trial

Affiliations
  • 1Asian Referral Center, Taipei 106, Taiwan. hsiao.derm@gmail.com
  • 2Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands.

Abstract

This study was conducted to evaluate the effects of cetirizine in dogs with atopic dermatitis (AD) while fulfilling Favrot's diagnostic clinical criteria. Dogs received either 3 mg/kg cetirizine (n = 27), or a placebo (n = 23) orally once daily for 14 days in a randomized, double blind, placebo-controlled study, without concomitant medication. The effects were evaluated using a pruritus visual analog scale at the start (day 0) and at day 14. After 14 days, cetirizine clearly had no effect on the pruritus in dogs with chronic AD, and there was no significant difference between groups. These findings indicated that cetirizine (and likely H1 histamine receptor antagonists in general) should not be recommended for the control of pruritus in dogs with long term allergies.

Keyword

atopic dermatitis; cetirizine; dogs; placebo-controlled study

MeSH Terms

Animals
Cetirizine/*therapeutic use
Chronic Disease
Dermatitis, Atopic/drug therapy/etiology/*veterinary
Dog Diseases/*drug therapy/etiology
Dogs
Double-Blind Method
Female
Histamine H1 Antagonists, Non-Sedating/*therapeutic use
Male
Treatment Outcome
Histamine H1 Antagonists, Non-Sedating
Cetirizine

Figure

  • Fig. 1 Individual and median group improvement (%) of dogs with atopic dermatitis treated with cetirizine (n = 27) or a placebo (n = 23).


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