Korean J Med.  2009 Aug;77(Suppl 1):S172-S178.

A case of posttransplantation lymphoproliferative disorder in hematopoietic stem cell transplantation

• Lee HY
• Koh SA
• Sohn SH
• Chin HJ
• Hyun MS
• Lee KH
• Kim MK

Abstract

Posttransplantation lymphoproliferative disorder (PTLD) is a potentially fatal complication of hematopoietic stem cell transplantation (HPSCT) that occurs relatively early after the transplantation. The occurrence of PTLD is usually associated with Epstein-Barr virus (EBV) infection in patients who are treated by aggressive immunosuppressive therapy. PTLD presents as diverse manifestations, ranging from reactive lymphoid hyperplasia to high grade malignant lymphoma. In the present work, we describe a case of PTLD that was successfully treated with R-CHOP (rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone) chemotherapy in a 21-year-old female who received HLA-matched sibling HPSCT for severe aplastic anemia. At 120 days after transplantation, she had symptoms of dysphagia and a foreign body sensation in the throat and was diagnosed as PTLD, diffuse large B cell lymphoma involving a tonsil, cervical lymph nodes, an adrenal gland, and the liver. Three courses of R-CHOP resulted in complete remission.

Keyword

Lymphoproliferative disorder; Stem cell transplantation; Rituximab; CHOP protocol

MeSH Terms

Adrenal Glands
Anemia, Aplastic
Antibodies, Monoclonal, Murine-Derived
Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Deglutition Disorders
Doxorubicin
Female
Foreign Bodies
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Herpesvirus 4, Human
Humans
Liver
Lymph Nodes
Lymphoma
Lymphoma, B-Cell
Lymphoproliferative Disorders
Palatine Tonsil
Pharynx
Prednisone
Pseudolymphoma
Sensation
Siblings
Stem Cell Transplantation
Transplants
Vincristine
Young Adult
Rituximab
Antibodies, Monoclonal, Murine-Derived
Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Doxorubicin
Prednisone
Vincristine