Korean J Nutr.  2004 May;37(4):273-280.

Effect of Dietary Iron Levels on Lipid Metabolism, Antioxidative and Antithrombogenic Capacities in 16-month-old Rats

Affiliations
  • 1Department of Food & Nutritional Sciences, Ewha Womans University, Seoul, Korea.

Abstract

This study was conducted to examine the effect of dietary iron levels on lipid metabolism, antioxidative and antithrombogenic capacities in 16-month-old rats. Thirty-two Sprague-Dawley male 16-month-old rats weighing 618 +/- 6 g were raised for 10 days with medium-iron diet (35 ppm in diet) and blocked into 4 groups according to their body weights. One of groups was sacrificed to obtain initial data and the rest 3 groups were raised for 3 months with experimental diets containing different levels of iron (5 ppm, 35 ppm, and 350 ppm). Total lipid, triglyceride and total cholesterol concentrations in plasma and liver, HDL-cholesterol concentration in plasma, fecal total lipid triglyceride and total cholesterol excretions, thiobarbituric acid reactive substances (TBARS) level in plasma LDL + VLDL (low density lipoprotein + very low density lipoprotein) fractions, blood-clotting time and eicosanoids levels in plasma were measured. The results are as follows: Plasma total lipid, triglyceride and total cholesterol concentrations, TBARS level in plasma LDL + VLDL fractions were increased and blood-clotting time tended to be shortened during 3 months of experimental period. Low (5 ppm) iron diet improved lipid metabolism via increasing HDL-cholesterol and fecal cholesterol excretion. High (350 ppm) iron diet decreased plasma total lipid, triglyceride and total cholesterol concentrations as compared to medium (35 ppm) iron diet and lowered body weight and epididymal fat pad weight. On the other hand, TBARS level in plasma LDL + VLDL fractions and blood-clotting time were increased with high iron diet. It is plausible that low iron diet improves lipid metabolism, antioxidative and antithrombogenic capacities in 16-month-old rats.

Keyword

iron; lipid metabolism; antioxidative capacity; antithrombogenic capacity; aged rats

MeSH Terms

Adipose Tissue
Animals
Body Weight
Cholesterol
Diet
Eicosanoids
Hand
Humans
Infant*
Iron
Iron, Dietary*
Lipid Metabolism*
Lipoproteins
Liver
Male
Plasma
Rats*
Rats, Sprague-Dawley
Thiobarbituric Acid Reactive Substances
Triglycerides
Cholesterol
Eicosanoids
Iron
Iron, Dietary
Lipoproteins
Thiobarbituric Acid Reactive Substances
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