Korean J Hematol.
2003 Aug;38(3):195-199.
A Case of Acute Panmyelosis with Myelofibrosis according to WHO Classification
- Affiliations
-
- 1Department of Laboratory Medicine, Asan Medical Center, Seoul, Korea. cjpark@amc.seoul.kr
- 2Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Abstract
- A 61-year-old man developed a rapidly progressive disease with anemia, thrombocytopenia and large number of blasts (10%) in the peripheral blood. The bone marrow revealed hypercellular marrow with extensive fibrosis and proliferation of immature cells of trilineage. Immunophenotyping and chromosome study with the bone marrow aspirate showed myeloblasts with aberrant expression of CD19 and complex karyotype including structural abnormalities within chromosome 5 and 7. After induction chemotherapy with Ara-c and daunorubicin, the number of blasts in peripheral blood was increased and the bone marrow showed hypercellular marrow with immature cells of trilineage and fibrosis. Cases like this have been called acute myelofibrosis, acute myelosclerosis or acute myelodysplasia with myelofibrosis. Recently this rare disease with rapidly fatal course was categorized into 'acute panmyelosis with myelofibrosis in acute myelogenous leukemia (AML) not otherwise categorized' by WHO classification.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Case of Acute Panmyelosis with Myelofibrosis
- Acute Panmyelosis with Myelofibrosis in Primary Myelodysplastic Syndrome
- Reduced Intensity Conditioning Regimen Followed by Allogeneic Peripheral Blood Stem Cell Transplantation for Acute Panmyelosis with Myelofibrosis
- A Case of Systemic Lupus Erythematosus with Myelofibrosis
- Two Cases of Myelofibrosis Mimicking Malignant Lymphoma in Computed Tomography of Abdomen: A Case of Autoimmune Myelofibrosis associated with Systemic Lupus Erythematosus Showing Extensive Lymphadenopathy and A Case of Chronic Idiopathic Myelofibrosis wit
