Korean J Lab Med.  2004 Aug;24(4):207-211.

A Case of Acute Panmyelosis with Myelofibrosis

• Lee YJ
• Park MR

Abstract

We experienced a case of acute panmyelosis with myelofibrosis, one of the acute myeloblastic leukemia (AML) subtypes according to WHO classification. A 44 year old man presented with a laborious dyspnea, dizziness, and generalized weakness. On admission, the peripheral blood revealed pancytopenia (hemoglobin 4.0 g/dL, WBC 2, 300/microliter, platelet 92, 000/microliter) with leukoerythroblastosis. The bone marrow (BM) aspirate yielded inadequate material but histological sections showed hyper-cellularity, proliferation of trilineage cell lines (panmyelosis) with extensive myelofibrosis, and clusters of immature cells at paratrabecular area. On ultrasonographic examination, no evidence of hepato-splenomegaly or any other abnormalities were noted. The follow-up BM study after the chemotherapy with Ara C for 7 days and idarubicin for 3 days showed no significant changes in pancytopenia and myelofibrosis but revealed a significant decrease in BM cellularity and blasts. We review and report the literature on acute panmyelosis with myelofibrosis.

Keyword

Acute panmyelosis with myelofibrosis; WHO classification; AML; Leukoerythrob-lastosis

MeSH Terms

Blood Platelets
Bone Marrow
Cell Line
Classification
Dizziness
Drug Therapy
Dyspnea
Follow-Up Studies
Idarubicin
Leukemia, Myeloid, Acute
Pancytopenia
Primary Myelofibrosis*
Idarubicin