Korean J Hematol.  2005 Mar;40(1):58-63. 10.5045/kjh.2005.40.1.58.

Two Cases of Acquired Hemophilia A Successfully Treated with Oral Steroid or Danazol

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. hemakim@yumc.yonsei.ac.kr

Abstract

Acquired Hemophilia A is a rare and considerably life-threatening coagulopathy, which is caused by the development of autoantibodies against factor VIII (FVIII) in non-hemophilic adults. Acquired FVIII inhibitors can be associated with diverse conditions, such as malignant disorders, medications, autoimmune diseases, postpartum states and others. These autoantibodies inhibit normal coagulation, had results in bleeding complications, which can contribute to mortality in a high percentages of cases. Effective control of the disorder can be achieved by prompt diagnosis and appropriate managements. Generally, the managements of acquired hemophilia A are aimed at treating the acute bleeding and eliminating inhibitors by immunosuppression. Although a range of treatment options exists for patients with acquired hemophilia A, there is no consensus with regard to the optimal therapies for this disorder. Herein, two cases, an 82-year-old man and a 78-year-old man who were successfully treated by steroid or danazol, which is a relatively mild immunosuppressive agent, are reported.

Keyword

Acquired hemophilia A; Factor VIII inhibitor; Immunosuppressive therapy

MeSH Terms

Adult
Aged
Aged, 80 and over
Autoantibodies
Autoimmune Diseases
Consensus
Danazol*
Diagnosis
Factor VIII
Hemophilia A*
Hemorrhage
Humans
Immunosuppression
Mortality
Postpartum Period
Autoantibodies
Danazol
Factor VIII
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