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The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A

Kim JY, You CW

BACKGROUND: Risk factors for the development of inhibitors in previously untreated patients (PUPs) have been reported; this is not the case in previously treated patients (PTPs) owing to fewer studies....
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Subgroup analysis of a phase 2/3 study of rurioctocog alfa pegol in patients with severe hemophilia A: efficacy and safety in previously treated Korean patients

You CW, Baek HJ, Park SK, Park YS, Shin HJ, Engl W, Tangada S

BACKGROUND: The efficacy and safety of extended half-life, full-length, pegylated recombinant factor VIII rurioctocog alfa pegol [BAX 855, ADYNOVATE (USA)/ADYNOVI (Europe); Baxalta US Inc., a Takeda company, Lexington, MA, USA]...
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Various Complications after a Vascular Procedure in Patients with Hemophilia

Ha YS, Park YS

Hemophilia, an inherited bleeding disorder, is caused by a deficiency of coagulation factor VIII or IX. Most of patients with hemophilia need vascular procedure, which can lead to complications. Even...
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Acquired Hemophilia in a Patient Presenting with Swollen Left Limb

Kiam GW

Acquired hemophilia is a rare, potentially life-threatening disease that usually remains under-recognized especially in a primary setting; thus, diagnosing this disease is very challenging. Given its prevalence in elderly patients,...
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Coagulation abnormalities and bleeding in pregnancy: an anesthesiologist's perspective

Yoon HJ

During pregnancy, the procoagulant activity increases (manifested by elevation in factor VII, factor VIII, factor X, and fibrinogen levels), while the anticoagulant activity decreases (characterized by reduction in fibrinolysis and...
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Spontaneous Retroperitoneal Hemorrhage Caused by Idiopathic Acquired Hemophilia A Misdiagnosed as a Delayed Traumatic Hematoma: A Case Report

Kim SH, Park SJ, Park CI, Choi SU, Kim JH

Acquired hemophilia A (AHA) is a rare disease where typically coagulation factor VIII is inhibited by autoantibodies. It occurs in patients with no personal or familial history of bleeding. In...
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Ultrasound-Guided Botulinum Toxin Injection with Factor VIII Administration for Post Stroke Spasticity in a Hemophilia A Patient

Shin MA, Lee SH, Lee JM, Shin JH

Chemodenervation with botulinum toxin (BTX) has been recommended for focal spasticity. BTX injection should be performed with caution in patients with bleeding disorders and/or receiving anticoagulation therapy. We present a...
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A Case of Stewart-Treves Syndrome on Lower Extremity Related to Hysterectomy and Total Hip Replacement Surgery

Song SE, Ro KW, Heo EP

  • KMID: 2436738
  • Korean J Dermatol.
  • 2018 Jul;56(6):376-379.
Stewart-Treves syndrome (STS) is a rare cutaneous angiosarcoma that develops in chronic lymphedema. The majority of STS is described in the upper extremity after aggressive locoregional therapy for breast cancer...
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Perioperative Management of Patients with Hemophilia during Spinal Surgery

Kobayashi , Imagama S, Ando K, Ito K, Tsushima M, Morozumi M, Tanaka S, Machino M, Ota K, Nishida Y, Ishiguro N

STUDY DESIGN: Single-center retrospective study. PURPOSE: To optimize the perioperative management of patients with hemophilia who are undergoing spinal surgery. OVERVIEW OF LITERATURE: Hemophilia is a rare disease in which there is...
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The 2nd Meeting of National Control Laboratories for Vaccines and Biologicals in the Western Pacific

Oh H, Shin J, Lee CK, Ochiai M, Nojima K, Lim CK, Raut S, Lisovsky I, Williams S, Yoo KY, Shin DY, Ato M, Ye Q, Han K, Lee C, Lee N, Hong JY, Jung K, Van Hung P, Jeong J

The Second Meeting of the National Control Laboratories for Vaccines and Biologicals in the Western Pacific, was jointly organized by the National Institute of Food and Drug Safety Evaluation of...
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Progress of Hemophilia A Therapeutics in Korea

Kim DH, Kim SK

Over the past several decades, hemophilia treatment in Korea has progressed dramatically. It has become possible to prevent hemophilia complications by maintenance treatment as well as on-demand treatment with the...
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Global hemostatic assay of different target procoagulant activities of factor VIII and factor IX

Yoo KY, Jung SY, Hwang SH, Lee SM, Park JH, Nam HJ

BACKGROUND: Korean National Health Insurance reimburses factor VIII (FVIII) and factor IX (FIX) clotting factor concentrate (CFC) infusions to discrepant activity levels, allowing elevation of FVIII activity to 60 IU/dL...
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Safety and Efficacy of B-domain Deleted Third Generation Recombinant Factor VIII (GreenGene Fâ„¢) in Korean Patients with Hemophilia A: Data from a Post-marketing Surveillance Study

Kim SK, Yoo KY, Lee KS, Hwang T, Choi YM, Choi EJ, Park SK

BACKGROUND: New B-domain deleted third generation recombinant factor VIII (FVIII; GreenGene Fâ„¢, beroctocog alfa) was launched in 2010. We determined safety and efficacy of GreenGene Fâ„¢ during routine clinical practice...
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Acquired Hemophilia A Combined with Systemic Lupus Erythematosus: A Case Report and Literature Review

You J, Kim H, Park JS, Chang MH, Lee CH

Acquired hemophilia A (AHA) is a rare hemorrhagic disorder caused by autoantibodies against factor VIII (FVIII). An 80-year-old woman presented multiple bruises on her upper and lower extremities, along with...
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Risk factors associated with provoked pulmonary embolism

Gjonbrataj E, Kim JN, Gjonbrataj J, Jung HI, Kim HJ, Choi WI

BACKGROUND/AIMS: This study aimed to investigate the risk factors associated with provoked pulmonary embolism (PE). METHODS: This retrospective cohort study included 237 patients with PE. Patients that had transient risk factors...
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Long-term course of anti-factor VIII antibody in patients with hemophilia A at a single center

Yoo KY, Joo SC, Choi YM

BACKGROUND: Immune tolerance induction (ITI) can reduce inhibitors against factor VIII concentrates by 70-80%. In this study, we elucidated the characteristics of inhibitors and attempted to determine the proper indications...
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Primary Cutaneous Carcinosarcoma Composed of Squamous Cell Carcinoma and Epithelioid Sarcoma

Noh SH, Chae JK, Park SH, Kim EJ, Park K

  • KMID: 2350796
  • Korean J Dermatol.
  • 2016 Feb;54(2):145-148.
Cutaneous carcinosarcoma is a biphasic, rare tumor composed of malignant epithelial and mesenchymal components. The most common carcinoma component is a squamous cell carcinoma and the most common sarcoma component...
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The activity of factor VIII and IX of cord blood at mid-trimester in fetuses without hemophilia

Choe DK, Oh JW, Jun JK, Choi YM

PURPOSE: Molecular genetic analysis is the main approach used for prenatal diagnosis of hemophilia A and B. However, in certain cases, such analysis is uninformative. In such situations, direct measurement...
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A Case of Cerebral Venous Thrombosis in a Patient with Graves' Disease

Kim BR, Jung JH, Hahm JR, Jung J, Park HJ, Kim SK

Superior sagittal sinus thrombosis is an uncommon disease, and 25% of cases are considered to be idiopathic. Hypercoagulability, local bloodstream stasis, and vessel wall abnormalities may contribute to the development...
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The efficacy of bypassing agents in surgery of hemophilia patients with inhibitors

Ju HY, Jang HL, Park YS

BACKGROUND: Inhibitory antibodies to factor VIII (FVIII) or IX (FIX) are important issues when managing patients with hemophilia A or B. Advances in bypassing agents such as recombinant activated FVII...
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