J Clin Neurol.  2006 Dec;2(4):286-289. 10.3988/jcn.2006.2.4.286.

Recurrent Cerebral Venous Thrombosis Associated with Elevated Factor VIII

• Kim MJ
• Cho AH
• No YJ
• Kim HY
• Kim JS

• KMID: 1980473
• DOI: http://doi.org/10.3988/jcn.2006.2.4.286

Abstract

Cerebral venous thrombosis (CVT) rarely recurs, and the factors associated with a recurrence remain unclear. Recently, however, elevated plasma coagulation factor VIII has been considered a factor related to recurrent venous thromboembolism. Here we report a patient who had recurrent CVT associated with significantly elevated levels of factor VIII despite the chronic use of an antiplatelet agent. Factor IX was also elevated in this patient. These findings suggest that elevated factor VIII is a factor underlying the recurrence of CVT, and that prolonged anticoagulation therapy may have to be considered in patients with elevated coagulation factor levels.

Keyword

Cerebral venous sinus thrombosis; Coagulation factor VIII

MeSH Terms

Blood Coagulation Factors
Factor IX
Factor VIII*
Humans
Plasma
Recurrence
Venous Thromboembolism
Venous Thrombosis*
Blood Coagulation Factors
Factor IX
Factor VIII

Figure

• 

  Figure 1 Brain computed tomography (CT) scan and conventional angiogram acquired at the time of the first attack. (A) CT scan showing a low-density area on the left frontal area (arrow). (B) Angiography revealed a filling defect in the superior sagittal sinus and irregular filling in the left transverse sinus (arrowheads).

• 

  Figure 2 CT findings at the time of the second attack. (A) Transverse sinus thrombosis with cord sign is visible on the right side (arrow). (B) CT showing venous infarction with hemorrhagic transformation in the right temporal area.

• 

  Figure 3 Conventional angiogram findings. (A) Occlusion of the right jugular vein (arrowhead) and transverse sinus (arrow). (B) After suction thrombectomy, the filling of the right internal jugular vein and transverse sinus had improved.

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