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Various Complications after a Vascular Procedure in Patients with Hemophilia

Ha YS, Park YS

Hemophilia, an inherited bleeding disorder, is caused by a deficiency of coagulation factor VIII or IX. Most of patients with hemophilia need vascular procedure, which can lead to complications. Even...
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Hemophilia A in a Female Patient with Recurrent Vitreous Hemorrhage

Kim HJ, Nam MS, Choo HK, Kim SH

PURPOSE: To report a case of recurrent intraocular hemorrhage due to type A hemophilia in a female patient without any previous medical history. CASE SUMMARY: A 51-year-old female patient without any...
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Coagulation abnormalities and bleeding in pregnancy: an anesthesiologist's perspective

Yoon HJ

During pregnancy, the procoagulant activity increases (manifested by elevation in factor VII, factor VIII, factor X, and fibrinogen levels), while the anticoagulant activity decreases (characterized by reduction in fibrinolysis and...
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Spontaneous Retroperitoneal Hemorrhage Caused by Idiopathic Acquired Hemophilia A Misdiagnosed as a Delayed Traumatic Hematoma: A Case Report

Kim SH, Park SJ, Park CI, Choi SU, Kim JH

Acquired hemophilia A (AHA) is a rare disease where typically coagulation factor VIII is inhibited by autoantibodies. It occurs in patients with no personal or familial history of bleeding. In...
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Perioperative Management of Patients with Hemophilia during Spinal Surgery

Kobayashi , Imagama S, Ando K, Ito K, Tsushima M, Morozumi M, Tanaka S, Machino M, Ota K, Nishida Y, Ishiguro N

STUDY DESIGN: Single-center retrospective study. PURPOSE: To optimize the perioperative management of patients with hemophilia who are undergoing spinal surgery. OVERVIEW OF LITERATURE: Hemophilia is a rare disease in which there is...
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The 2nd Meeting of National Control Laboratories for Vaccines and Biologicals in the Western Pacific

Oh H, Shin J, Lee CK, Ochiai M, Nojima K, Lim CK, Raut S, Lisovsky I, Williams S, Yoo KY, Shin DY, Ato M, Ye Q, Han K, Lee C, Lee N, Hong JY, Jung K, Van Hung P, Jeong J

The Second Meeting of the National Control Laboratories for Vaccines and Biologicals in the Western Pacific, was jointly organized by the National Institute of Food and Drug Safety Evaluation of...
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Tissue factor expression is associated with recurrence in patients with non-metastatic colorectal cancer

Jung HJ, Kim HJ, Kaneko K, Kazama Y, Kawai K, Ishihara S, Choi GS

PURPOSE: Previous studies have addressed the role of the hypercoagulable state in the pathogenesis of cancer progression and metastasis. In this study, we investigated the association between coagulation factors, including...
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The Current Global Status and Production Trends of Plasma Fractionation

Kim MJ, Burnouf T

The demand for medicinal products derived from plasmas are increasing on a global scale. In particular, the demand for intravenous immunoglobulin has continuously been increasing. The increase in the capacity...
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Successful Non-operative Management of Intra-abdominal Hemorrhage in Two Patients with Hemophilia A

Kim MJ, Lee EH, Yoon HS

Spontaneous intra-abdominal hemorrhages are uncommon in hemophilic patients. They can cause complications in patients with severe hemophilia, and are associated with a high mortality rate. To date, there is no...
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Cerebral Palsy due to Intracranial Hemorrhage Caused by Consumptive Coagulopathy in Protein C Deficiency: A Case Report

Cho Y, Lee YM, Park ES, Choi JY, Park C, Rha DW

Protein C (PROC) is a potent anticoagulant inactivating coagulation factors Va and VIIIa. PROC deficiency is very rare condition inherited as an autosomal dominant or recessive trait, and associated with...
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Anticoagulation in Patients with Liver Cirrhosis

Cheong JY

Cirrhotic patients have bleeding tendencies due to the lack of coagulation factors and thrombocytopenia. However, decreased levels of procoagulants are also accompanied by decreased levels of natural anticoagulants. However, there...
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Bone Density Status in Bleeding Disorders: Where Are We and What Needs to Be Done?

Mansouritorghabeh H, Rezaieyazdi Z

Bleeding disorders, including hemophilia, can be seen in every ethnic population in the world. Among various bleeding disorders, reduced bone density has been addressed in hemophilia A. In recent years,...
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The activity of factor VIII and IX of cord blood at mid-trimester in fetuses without hemophilia

Choe DK, Oh JW, Jun JK, Choi YM

PURPOSE: Molecular genetic analysis is the main approach used for prenatal diagnosis of hemophilia A and B. However, in certain cases, such analysis is uninformative. In such situations, direct measurement...
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Role of Coagulation Factor 2 Receptor during Respiratory Pneumococcal Infections

Shin SG, Bong Y, Lim JH

Coagulation factor 2 receptor (F2R), also well-known as a protease-activated receptor 1 (PAR1), is the first known thrombin receptor and plays a critical role in transmitting thrombin-mediated activation of intracellular...
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Moderate Hemophilia B Diagnosed by Massive Gastrointestinal Hemorrhage on the First Day of Life: A Case Report and Literature Review

Park SH, Choe BH

Gastrointestinal hemorrhage in neonates is commonly associated with necrotizing enterocolitis, cow's milk protein allergy, and gastrointestinal malformation. Gastrointestinal bleeding on the first day of life, presenting as the first manifestation...
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Utilization Patterns of Coagulation Factor Consumption for Patients with Hemophilia

Lee SO, Yu SY

Hemophilia is a serious rare disease that requires continuous management and treatment for which the medicine is costly at the annual average of 100 million KRW for an individual. The...
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Activation of the Intrinsic Coagulation Pathway in Patients With Chronic Urticaria

Kim JA, Kim S, Kim JE, Gu JY, Yoo HJ, Kang HR, Kim HK

PURPOSE: Although coagulation activation has been reported in chronic urticaria, data pertaining to detailed changes in coagulation factors and global coagulation status are lacking. The current study evaluated global coagulation...
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Chronic Rhinosinusitis and the Coagulation System

Kim DY, Cho SH, Takabayashi T, Schleimer

Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in adults and severely affects quality of life in patients. Although various etiologic and pathogenic mechanisms of CRS have...
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Oral Rivaroxaban Treatment for L-asparaginase-induced Deep Thrombophlebitis in Lower Extremity

Kim JE, Kim JY

We are reporting our experience of oral rivaroxaban (Xarelto(R)) treatment for L-asparaginase (L-ASP)-induced deep vein thrombophlebitis in the lower extremity developed during childhood acute lymphoblastic leukemia (ALL) chemotherapy, with a...
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A Choice and Precautions of Replacement Fluids for Therapeutic Plasma Exchange

Choi GR, Choi SJ, Shin SA, Lee K, Kim S, Kim HO

BACKGROUND: Therapeutic plasma exchange (TPE) is an effective and practical treatment for separation and removal of harmful antibodies or pathogenic substances from the blood. The volume of plasma removed must...
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