J Korean Ophthalmol Soc.  1993 Sep;34(9):881-888.

Effect of Plasma Coagulation Factor XIII Deficiency on the Healing Following Trabeculectomy in Rabbits

Affiliations
  • 1Department of Ophthalmology, Catholic University, Medical College, Holy Family Hospital, Pucheon, Korea.

Abstract

Conjunctival fibroblastic proliferation with contracting scar formation has been implicated as a possible cause of glaucoma filtering surgery failure. The inhibitory effect of plasma coagulation factor XIII deficiency on the healing following trabeculectomy of the eyes in rabbits was studied. The plasma coagulation factor XIII deficiency was induced by two successive intravenous injections of anti-rabbit plasma coagulation factor XIII-goat immunoglobulin. Grossly, artificially prepared filtering bleb was well preserved on plasma coagulation factor XIII ddicient groups compared with control groups. Histologically. wound healing following trabeculectomy was delayed and the size of the scar was reduced on plasma coagulation factor XIII deficient groups compared with control groups. The above findings suggest that plasma coagulation factor XIII deficiency inhibit the healing precess following traheculectomy.

Keyword

Filtering bleb; Plasma coagulation factor XIII; Trabeculectomy; Wound healing

MeSH Terms

Blister
Blood Coagulation Factors*
Cicatrix
Factor XIII*
Fibroblasts
Filtering Surgery
Glaucoma
Immunoglobulins
Injections, Intravenous
Plasma*
Rabbits*
Trabeculectomy*
Wound Healing
Blood Coagulation Factors
Factor XIII
Immunoglobulins
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