J Korean Med Sci.  1991 Mar;6(1):1-6. 10.3346/jkms.1991.6.1.1.

A study on changes of coagulation inhibitors and fibrinolysis inhibitors in patients with liver cirrhosis and hepatoma

• Park CJ
• Cho HI
• Kim SI

• KMID: 1421508
• DOI: http://doi.org/10.3346/jkms.1991.6.1.1

Abstract

The authors conducted an investigation focusing mainly on the activities of the inhibitory factors of the coagulation and fibrinolysis processes in 35 normal adults and 72 liver cirrhosis and/or hepatoma patients. The activities of antithrombin III, protein C, and alpha 2-plasmin inhibitor were reduced to less than 50% in patients with decreased hepatic synthetic function while lupus anticoagulant was detected in more than 50% of patients with decreased hepatic synthetic function. Hemostatic abnormalities in advanced lived diseases may be caused partly by a decrease of coagulation and fibrinolysis inhibitors and the presence of lupus anticoagulant.

Keyword

Coagulation and fibrinolysis inhibitors; Liver cirrhosis

MeSH Terms

Adult
Antifibrinolytic Agents/blood
Blood Coagulation Factors/antagonists & inhibitors/immunology/metabolism
Carcinoma, Hepatocellular/*blood
Hemostasis
Humans
Liver Cirrhosis/*blood
Liver Neoplasms/*blood
Lupus Coagulation Inhibitor
Antifibrinolytic Agents
Blood Coagulation Factors
Lupus Coagulation Inhibitor