Korean J Anesthesiol.  2007 May;52(5):609-611. 10.4097/kjae.2007.52.5.609.

Clinical Experience with Recombinant Activated Factor VII in a Surgical Patient with Coagulation Factor VII Deficiency: A case report

• Kim SH
• Lim KJ
• Yoon SZ
• Park KS
• Do SH

• KMID: 2239885
• DOI: http://doi.org/10.4097/kjae.2007.52.5.609

Abstract

A 33-yr old female patient with coagulation factor VII deficiency was scheduled for laparoscopic oophorectomy under the diagnosis of ovarian teratoma. Plasma concentration of factor VII of this patient was 9 IU/dl (normal range; 60-140 IU/dl) and the prothrombin time INR (International Normalization Ratio) was 1.79 (normal range; 0.8-1.2) on the day before the operation. Total 1,200microgram (30microgram/kg) of recombinant activated factor VII (rFVIIa) was administered just before the start of the laparoscopic procedure, which was accomplished safely without severe hemorrhage or other complications. Postoperative course was uneventful. In addition, this article provides the clinical implication of rFVIIa in terms of hemostasis management in hemophiliacs and surgical patients.

Keyword

blood coagulation; coagulation factor VII deficiency; recombinant activated factor VII

MeSH Terms

Blood Coagulation
Blood Coagulation Factors*
Diagnosis
Factor VII*
Factor VIIa*
Female
Hemorrhage
Hemostasis
Humans
International Normalized Ratio
Ovariectomy
Plasma
Prothrombin Time
Teratoma
Blood Coagulation Factors
Factor VII
Factor VIIa