Korean J Pediatr.  2010 Oct;53(10):913-916. 10.3345/kjp.2010.53.10.913.

A case of intracranial hemorrhage in a neonate with congenital factor VII deficiency

• Lee WS
• Park YS

• KMID: 2011556
• DOI: http://doi.org/10.3345/kjp.2010.53.10.913

Abstract

Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder. Bleeding manifestations and clinical findings vary widely, ranging from asymptomatic subjects to patients with hemorrhages that may cause significant handicaps. Treatment has traditionally involved factor VII(FVII) replacement therapy using fresh frozen plasma, prothrombin complex concentrates or plasma-derived FVII concentrates. Recombinant activated FVII (NovoSeven(R)) is currently considered the first-line treatment for replacement therapy of FVII deficiency. Here we present a case of severe intracerebral and intraventricular hemorrhage in a neonate with congenital FVII deficiency.

Keyword

Congenital factor VII deficiency; Intracranial hemorrhage; Neonate

MeSH Terms

Blood Coagulation Factors
Factor VII
Factor VII Deficiency
Hemorrhage
Humans
Infant, Newborn
Intracranial Hemorrhages
Plasma
Prothrombin
Blood Coagulation Factors
Factor VII
Prothrombin