Yeungnam Univ J Med.
2004 Dec;21(2):231-236.
A Case of Congenital Factor VII Deficiency Presented with Subacute Subdural Hematoma
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea. hms@medical.yu.ac.kr
- 2Department of Laboratory Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
Abstract
- A congenital factor VII deficiency is a rare disorder with an estimated incidence in the western contries of one in 500, 000. Because factor VII is important in initiation the coagulation cascade, a factor VII deficiency can result in significant bleeding with prolongation of the prothrombin time. We present a case of a factor VII deficiency with a subdural hematoma in an 18-year-old boy whose plasma activity of factor VII was < or =10%. Previously, he did not have any symptoms, such as hemarthrosis, easy bruising or bleeding after a minor trauma. He was administered fresh frozen plasma and a trephination was performed. His sister also had 51% lower level of factor VII.
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