Korean J Blood Transfus.  2012 Apr;23(1):68-71.

Acquired Hemophilia: Successfully Treated with Plasma Exchange in a Patient with Hightiter Inhibitors

  • 1Department of Clinical Pathology, School of Medicine, Kyungpook Natioanl University, Daegu, Korea. suhjs@knu.ac.kr


Acquired hemophilia is an extremely rare but life threatening hemorrhagic disease caused by autoantibodies directed coagulation factor VIII. Estimated management guidelines include rapid diagnosis, suppression of bleeding, and elimination of inhibitors by use of immunosuppressants. Plasma exchange is used restrictively as an adjuvant in order to lower the level of inhibitor. We report on a successful therapeutic experience with plasma exchange in a patient with refractory acquired hemophilia. After performance of the plasma exchange procedure, bleeding was controlled and results of coagulation tests showed improvement according to the decrease in levels of factor VIII inhibitor.


Acquired hemophilia; Factor VIII inhibitor; Plasma exchange
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