Korean J Biol Psychiatry.
2005 May;12(1):62-67.
The CDH2 Gene Polymorphism in Schizophrenia
- Affiliations
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- 1Seoul National Mental Hospital, Seoul, Korea.
- 2Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital, Buchoen, Korea. hanyjung@schbc.ac.kr
- 3Department of Neuropsychiatry, College of Medicine, Kyunghee University Hospital, Seoul, Korea.
- 4Department of Pharmacology, College of Medicine, Kangwon University Hospital, Chuncheon, Korea.
Abstract
OBJECTIVE
There has been increasing evidence that neurodevelopmental dysfunction is involved in the pathophysiology of schizophrenia. Cadherin is known to be one of the important molecules in neurodevelopment. This study was performed to examine the relationship between T816C polymorphism of CDH2 gene and schizophrenia.
METHODS
Genoytypes of T816C polymorphism of CDH2 gene were analyzed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) in 156 Korea patents with schizophrenia and 170 controls.
RESULTS
No difference was found between the patients with schizophrenia and the controls in genotype and allele frequencies of T816C polymorphism of CDH2 gene.
CONCLUSION
The results of this study do not support an association between T816C polymorphism of CDH2 gene and schizophrenia. However, it is necessary to investigate other polymorphic regions of CDH2 in schizophrenia.
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