Korean J Dermatol.  2013 Mar;51(3):219-222.

A Case of Epidermolysis Bullosa Simplex (Other Generalized Type)

• Ko DY
• Ha SM
• Jeon SY
• Kim DC
• Song KH
• Kim KH

Abstract

The other generalized type of epidermolysis bullosa simplex (EBS) is a genetic blistering skin disease, caused by a mutation of the genes encoding keratin 5 and 14. EBS starts at birth and is characterized by generalized blisters following a minor trauma that heals with hyperpigmentation. A 19-year-old man presented with 19-year history of multiple erythematous vesicles in a herpetiform arrangement on the trunk, axilla, and thigh with post-inflammatory hyper-pigmentations. On light and electron microscopy, the biopsy specimen showed intraepidermal blisters that formed within the basal keratinocyte. The serum from a patient with bullous pemphigoid antibody and laminin 5 antibody showed the linear deposition at the floor of the blister on immunofluorescence mapping study. On the basis of our clinical, microscopic, and immunofluorescence findings, we diagnosed the patient as having a generalized type of EBS. Herein, we report on an interesting case of the other generalized type of EBS.

Keyword

Other generalized type of epidermolysis bullosa simplex

MeSH Terms

Axilla
Biopsy
Blister
Cell Adhesion Molecules
Epidermolysis Bullosa
Epidermolysis Bullosa Simplex
Floors and Floorcoverings
Fluorescent Antibody Technique
Humans
Hyperpigmentation
Keratin-5
Keratinocytes
Laminin
Light
Methylmethacrylates
Microscopy, Electron
Parturition
Pemphigoid, Bullous
Polystyrenes
Skin Diseases
Thigh
Cell Adhesion Molecules
Keratin-5
Laminin
Methylmethacrylates
Polystyrenes