- LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer
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Kunitomi H, Kobayashi , Wu RC, Takeda T, Tominaga E, Banno K, Aoki D
- KMID: 2470864
- J Gynecol Oncol.
- 2020 Mar;31(2):e11.
- doi: 10.3802/jgo.2020.31.e11
OBJECTIVE: With the emerging significance of genetic profiles in the management of endometrial cancer, the identification of tumor-driving genes with prognostic value is a pressing need. The LAMC1 gene, encoding... -
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- Preparation and Characterization of Human Adipose Tissue-Derived Extracellular Matrix, Growth Factors, and Stem Cells: A Concise Review
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Chun SY, Lim JO, Lee EH, Han MH, Ha YS, Lee JN, Kim BS, Park MJ, Yeo M, Jung B, Kwon TG
- KMID: 2455047
- Tissue Eng Regen Med.
- 2019 Aug;16(4):385-393.
- doi: 10.1007/s13770-019-00199-7
BACKGROUND: Human adipose tissue is routinely discarded as medical waste. However, this tissue may have valuable clinical applications since methods have been devised to effectively isolate adipose-derived extracellular matrix (ECM),... -
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- Adipose-Derived Stem Cell Coculturing Stimulates Integrin-Mediated Extracellular Matrix Adhesion of Melanocytes by Upregulating Growth Factors
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Kim H, Yi N, Do BR, Lee AY
- KMID: 2442010
- Biomol Ther.
- 2019 Feb;27(2):185-192.
- doi: 10.4062/biomolther.2018.203
Coculture with adipose-derived stem cells (ADSCs) can stimulate proliferation and migration of melanocytes. To enhance outcomes of skin disorders caused by melanocyte loss or death, mixed transplantation with ADSCs has... -
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- Laminin and Platelet-Derived Growth Factor-BB Promote Neuronal Differentiation of Human Urine-Derived Stem Cells
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Kim JY, Chun SY, Park JS, Chung JW, Ha YS, Lee JN, Kwon TG
- KMID: 2410514
- Tissue Eng Regen Med.
- 2018 Apr;15(2):195-209.
- doi: 10.1007/s13770-017-0102-x
Urine-derived stem cells (USCs) are considered as a promising cell source capable of neuronal differentiation. In addition, specific growth factors and extracellular matrix are essential for enhancing their neuronal differentiation... -
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- Effects of Human Serum on Human Corneal Epithelial Cells in Vitro
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Park YM, Park JS, Lee IH, Lee JS
- KMID: 2397847
- J Korean Ophthalmol Soc.
- 2017 Dec;58(12):1333-1340.
- doi: 10.3341/jkos.2017.58.12.1333
PURPOSE: To investigate the effect of human serum on corneal epithelial cells. METHODS: Changes of corneal epithelial cells were evaluated after 1, 4, 12, and 24 hours (hrs) of exposure to... -
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- Enrichment and In Vitro Culture of Spermatogonial Stem Cells from Pre-Pubertal Monkey Testes
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Kim YH, Kang HG, Kim BJ, Jung SE, Karmakar P, Kim SM, Hwang S, Ryu BY
- KMID: 2394989
- Tissue Eng Regen Med.
- 2017 Oct;14(5):557-566.
- doi: 10.1007/s13770-017-0058-x
Spermatogonial stem cells (SSCs) are essential for spermatogenesis throughout the lifespan of the male. However, the rarity of SSCs has raised the need for an efficient selection method, but little... -
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- Laminin Modulates the Stem Cell Population in LM05-E Murine Breast Cancer Cells through the Activation of the MAPK/ERK Pathway
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Berardi DE, Raffo D, Todaro LB, Simian M
- KMID: 2394806
- Cancer Res Treat.
- 2017 Oct;49(4):869-879.
- doi: 10.4143/crt.2016.378
PURPOSE: We investigated the effects of laminin on the fraction of cells with self-renewing capacity in the estrogen-dependent, tamoxifen-sensitive LM05-E breast cancer cell line. We also determined whether laminin affected... -
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- Paraneoplastic Pemphigus Associated with a Malignant Thymoma: A Case of Persistent and Refractory Oral Ulcerations Following Thymectomy
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Lim JM, Lee SE, Seo J, Kim DY, Hashimoto , Kim SC
- KMID: 2394848
- Ann Dermatol.
- 2017 Apr;29(2):219-222.
- doi: 10.5021/ad.2017.29.2.219
Paraneoplastic pemphigus is a rare, life-threatening autoimmune mucocutaneous blistering disease associated with underlying neoplasia, commonly lymphoproliferative tumors. Herein we report a case of paraneoplastic pemphigus with a unique autoantibody profile... -
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- Phytoestrogen (Daidzein) Promotes Chondrogenic Phenotype of Human Chondrocytes in 2D and 3D Culture Systems
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Mahmod SA, Snigh S, Djordjevic I, Yee YM, Yusof R, Ramasamy T, Rothan HA
- KMID: 2377340
- Tissue Eng Regen Med.
- 2017 Apr;14(2):103-112.
- doi: 10.1007/s13770-016-0004-3
Clinical investigations have shown a significant relationship between osteoarthritis (OA) and estrogens levels in menopausalwomen. Therefore, treatment with exogenous estrogens has been shownto decrease the risk ofOA.However, the effect estrogen... -
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- Polycaprolactone Triol–Citrate Scaffolds Enriched with Human Platelet Releasates Promote Chondrogenic Phenotype and Cartilage Extracellular Matrix Formation
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Rothan HA, Mahmod SA, Djordjevic I, Golpich M, Yusof R, Snigh S
- KMID: 2377339
- Tissue Eng Regen Med.
- 2017 Apr;14(2):93-101.
- doi: 10.1007/s13770-017-0023-8
In this paper we report the differentiating properties of platelet-rich plasma releasates (PRPr) on human chondrocytes within elastomeric polycaprolactone triol–citrate (PCLT–CA) porous scaffold. Human-derived chondrocyte cellular content of glycosaminoglycans (GAGs)... -
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- Parameters of Stromal Activation and Epithelial to Mesenchymal Transition as Predictive Biomarkers for Induction Chemotherapy in Patients With Locally Advanced Oral Cavity and Oropharyngeal Squamous Cell Cancer
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Geweiler J, Inhestern , Berndt A, Guntinas-Lichius O
- KMID: 2360771
- Clin Exp Otorhinolaryngol.
- 2016 Dec;9(4):374-381.
- doi: 10.21053/ceo.2015.01683
OBJECTIVES: Induction chemotherapy (IC) is likely to be effective for biologically distinct subgroups of oral cancer and biomarker development may lead to identification of those patients. METHODS: We evaluated immune cell... -
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- Merosin-Deficient Congenital Muscular Dystrophy with Polymicrogyria and Subcortical Heterotopia: A Case Report
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Han YM, Lee NR, Bae MH, Park KH, Shin JH, Kim DS, Byun SY
- KMID: 2350288
- Neonatal Med.
- 2016 Aug;23(3):173-177.
- doi: 10.5385/nm.2016.23.3.173
This paper reports the brain magnetic resonance imaging (MRI) findings of a case of merosin-deficient congenital muscular dystrophy (MDCMD) in a neonate and discusses the spectrum of brain involvement in... -
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- Liver Shear-Wave Velocity and Serum Fibrosis Markers to Diagnose Hepatic Fibrosis in Patients with Chronic Viral Hepatitis B
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Liu J, Ji Y, Ai H, Ning B, Zhao J, Zhang Y, Dun G
- KMID: 2451413
- Korean J Radiol.
- 2016 Jun;17(3):396-404.
- doi: 10.3348/kjr.2016.17.3.396
OBJECTIVE: To compare several noninvasive indices of fibrosis in chronic viral hepatitis B, including liver shear-wave velocity (SWV), hyaluronic acid (HA), collagen type IV (CIV), procollagen type III (PCIII), and... -
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- Long-Duration Three-Dimensional Spheroid Culture Promotes Angiogenic Activities of Adipose-Derived Mesenchymal Stem Cells
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Lee JH, Han YS, Lee SH
- KMID: 2164218
- Biomol Ther.
- 2016 May;24(3):260-267.
- doi: 10.4062/biomolther.2015.146
Mesenchymal stem cells (MSCs) offer significant therapeutic promise for various regenerative therapies. However, MSC-based therapy for injury exhibits low efficacy due to the pathological environment in target tissues and the... -
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- Nfic regulates tooth root patterning and growth
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Kim TH, Bae CH, Yang S, Park JC, Cho ES
- KMID: 2424821
- Anat Cell Biol.
- 2015 Sep;48(3):188-194.
- doi: 10.5115/acb.2015.48.3.188
Molecular interactions between epithelium and mesenchyme are important for root formation. Nuclear factor I-C (Nfic) has been identified as a key regulator of root formation. However, the mechanisms of root... -
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- Comparative Analysis of the Extracellular Matrix Composition in Proliferating and Involuted Infantile Hemangiomas
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Park H, Park H, Chung HY, O TM, Waner M
- KMID: 2391868
- Arch Plast Surg.
- 2015 Sep;42(5):544-551.
- doi: 10.5999/aps.2015.42.5.544
BACKGROUND: Changes in the composition of the extracellular matrix (ECM) occur between the proliferating and involuted phases of infantile hemangiomas (IH), and are associated with angiogenic growth. We examined the... -
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- Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist's Perspective
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Jang TY, Kim YH
- KMID: 2380842
- Int Neurourol J.
- 2015 Sep;19(3):142-150.
- doi: 10.5213/inj.2015.19.3.142
Interleukin (IL) 33, a member of the IL-1 superfamily, is an "alarmin" protein and is secreted in its active form from damaged cells undergoing necrotic cell death. Mast cells are... -
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- Effect of Bevacizumab on Human Tenon's Fibroblasts Cultured from Primary and Recurrent Pterygium
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Park YM, Kim CD, Lee JS
- KMID: 2285579
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):357-363.
- doi: 10.4196/kjpp.2015.19.4.357
The purpose of this study was to compare the inhibitory effect of bevacizumab on human Tenon's fibroblasts (HTFs) cultured from primary and recurrent pterygium. Cultured HTFs were exposed to 2.0,... -
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- Neurosphere and adherent culture conditions are equivalent for malignant glioma stem cell lines
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Rahman M, Reyner K, Deleyrolle L, Millette S, Azari H, Day BW, Stringer B, Boyd AW, Johns TG, Blot V, Duggal R, Reynolds B
- KMID: 2046072
- Anat Cell Biol.
- 2015 Mar;48(1):25-35.
- doi: 10.5115/acb.2015.48.1.25
Certain limitations of the neurosphere assay (NSA) have resulted in a search for alternative culture techniques for brain tumor-initiating cells (TICs). Recently, reports have described growing glioblastoma (GBM) TICs as... -
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- Congenital muscular dystrophy type 1A with residual merosin expression
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Kim HJ, Choi YC, Park HJ, Lee YM, Kim HD, Lee JS, Kang HC
- KMID: 1702654
- Korean J Pediatr.
- 2014 Mar;57(3):149-152.
- doi: 10.3345/kjp.2014.57.3.149
Congenital muscular dystrophy type 1A (MDC1A) is an autosomal recessive disorder characterized by hypotonia, elevated serum creatine kinase level, delayed motor milestones, white matter changes observed by brain magnetic resonance... -
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