Korean J Anesthesiol.  2008 Feb;54(2):185-188. 10.4097/kjae.2008.54.2.185.

Effect of Nalbuphine on Emergence Agitation and Recovery after Desflurane Anesthesia in Children for Strabismus Surgery

• Chang H
• Hong SH
• Lee J
• Park CM
• Ryu KH
• Han HJ
• Lee Y

• KMID: 2244021
• DOI: http://doi.org/10.4097/kjae.2008.54.2.185

Abstract

BACKGROUND: Emergence agitation frequently occurs after desflurane anesthesia in children.Nalbuphine, because of its sedative and analgesic properties, might be useful for the management of this side effect.We studied the effect of nalbuphine on recovery characteristics and emergence agitation after desflurane anesthesia in children for strabismus surgery.
METHODS
41 patients (3-14 yr) scheduled for pediatric strabismus surgery were included.All children received ketamine 0.5 mg/kg intravenously before entering the operating room.After intravenous induction with thiopental and rocuronium to facilitate endotracheal intubation, patients were randomly assigned to receive saline, or nalbuphine 0.2 mg/kg respectively. Anesthesia was maintained with desflurane 4-6% with N2O : O2 = 2 : 1.At the end of anesthesia, time to cough, extubation, movement, eye opening and discharge were recorded.Emergence agitation was recorded by three point rating scale.
RESULTS
Agitation scores were significantly different between the two groups (P < 0.01).Time to extubation and movement were similar between two groups.Time to eye opening was significantly increased in nalbuphine group (P < 0.05).But, there was no difference in time to discharge from the recovery room to the ward between the two groups.
CONCLUSIONS
In children undergoing strabismus surgery with desflurane anesthesia, nalbuphine 0.2 mg/kg administered immediately after induction reduced incidence of emergence agitation without delaying discharge from recovery room.

Keyword

desflurane; emergence agitation; nalbuphine; recovery; strabismus surgery

MeSH Terms

Androstanols
Anesthesia
Child
Cough
Dihydroergotamine
Eye
Eye Movements
Humans
Incidence
Intubation, Intratracheal
Isoflurane
Ketamine
Nalbuphine
Recovery Room
Strabismus
Thiopental
Androstanols
Dihydroergotamine
Isoflurane
Ketamine
Nalbuphine
Thiopental