Korean J Anesthesiol.  2008 Nov;55(5):575-578. 10.4097/kjae.2008.55.5.575.

Effects of propofol and nalbuphine on emergence agitation after sevoflurane anesthesia in children for strabismus surgery

• Kim HJ
• Kim HS
• Kim SD
• Kim CS
• Kim JT
• Lee KJ
• Park SJ

• KMID: 2242997
• DOI: http://doi.org/10.4097/kjae.2008.55.5.575

Abstract

BACKGROUND
Emergence agitation in children is frequently associated with sevoflurane general anesthesia. We measured the effects of propofol and nalbuphine on emergence agitation after sevoflurane anesthesia in children for strabismus surgery.
METHODS
Ninety pediatric patients receiving sevoflurane anesthesia for elective strabismus surgery were enrolled. They were randomized to receive either saline (Group S), propofol 1 mg/kg (Group P), or nalbuphine 0.1 mg/kg (Group N) at the end of surgery. We evaluated the incidence of emergence agitation and recovery in the postanesthesia care unit.
RESULTS
The time to recovery was similar between the three study groups. The incidence of agitation was significantly lower in Group N compared with Group S, but the incidence of agitation between Group S and Group P was not different.
CONCLUSIONS
Nalbuphine 0.1 mg/kg at the end of strabismus surgery under sevoflurane anesthesia effectively reduced emergence agitation in children without delaying recovery, but propofol did not.

Keyword

emergence agitation; nalbuphine; propofol; sevoflurane

MeSH Terms

Anesthesia
Anesthesia, General
Child
Dihydroergotamine
Humans
Incidence
Methyl Ethers
Nalbuphine
Propofol
Strabismus
Dihydroergotamine
Methyl Ethers
Nalbuphine
Propofol